| Name | NTRK1 |
| ID | P04629 |
| Role | kinase |
| Enzymatic Domains |
LRRCT 148-193
Ig-like C2-type 1 194-283 PROSITE-ProRule
Ig-like C2-type 2 299-365 PROSITE-ProRule
Protein kinase 510-781 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NTRK1 | SH2B2 | – | phosphorylation up-regulates | 9856458 | SIGNOR-62619 | |
| NTRK1 | NTRK1 | Tyr496 | HIIENPQyFSDACVH | phosphorylation up-regulates | 9099755 | SIGNOR-47167 |
| NTRK1 | NTRK1 | Tyr676 | FGMSRDIySTDYYRV | phosphorylation up-regulates | 9099755 | SIGNOR-47171 |
| NTRK1 | NTRK1 | Tyr680 | RDIYSTDyYRVGGRT | phosphorylation up-regulates | 9099755 | SIGNOR-47175 |
| NTRK1 | NTRK1 | Tyr681 | DIYSTDYyRVGGRTM | phosphorylation up-regulates | 9099755 | SIGNOR-47179 |
| NTRK1 | NTRK1 | Tyr791 | LAQAPPVyLDVLG | phosphorylation up-regulates | 9099755 | SIGNOR-47183 |
| NTRK1 | PLCG1 | – | phosphorylation up-regulates | 8384556 | SIGNOR-38538 | |
| NTRK1 | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation up-regulates activity | 22558232 | SIGNOR-279240 |
| NTRK1 | SHC3 | Tyr218 | GDGSDHPyYNSIPSK | phosphorylation up-regulates activity | 11791173 | SIGNOR-273913 |
| NTRK1 | SHC3 | Tyr219 | DGSDHPYyNSIPSKM | phosphorylation up-regulates activity | 11791173 | SIGNOR-273915 |
| NTRK1 | SHC3 | Tyr283 | RQGSSDIySTPEGKL | phosphorylation up-regulates activity | 11791173 | SIGNOR-273914 |
| NTRK1 | SHC3 | Tyr301 | PTGEAPTyVNTQQIP | phosphorylation up-regulates activity | 11791173 | SIGNOR-273923 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr496 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47167 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr676 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47171 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr680 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47175 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr681 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47179 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr791 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47183 |
| NTRK1 | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation up-regulates → | CTNNB1 | 22558232 | SIGNOR-279240 |
| NTRK1 | phosphorylation up-regulates → | SHC3 PTyr218 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273913 |
| NTRK1 | phosphorylation up-regulates → | SHC3 PTyr219 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273915 |
| NTRK1 | phosphorylation up-regulates → | SHC3 PTyr283 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273914 |
| NTRK1 | phosphorylation up-regulates → | SHC3 PTyr301 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273923 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NTRK1 | phosphorylation → up-regulates | SH2B2 | SIGNOR-62619 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47167 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47171 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47175 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47179 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47183 |
| NTRK1 | phosphorylation → up-regulates | PLCG1 | SIGNOR-38538 |
| NTRK1 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-279240 |
| NTRK1 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273913 |
| NTRK1 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273915 |
| NTRK1 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273914 |
| NTRK1 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273923 |