Summary

Name NTRK1
Full Name High affinity nerve growth factor receptor
Synonyms Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA | MTC, TRK, TRKA
Primary ID P04629
Links - -
Type protein
Relations 20
Inhibitors regorafenib; LSM-1231; anthra[1,9-cd]pyrazol-6(2H)-one
Function Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation NTRK1 0.32
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation NTRK1 0.08
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding FRS2 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NTRK1 0.57
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NTRK1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, phosphorylation PLCG1 0.53
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition NTRK1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SH2B2 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition NTRK1 0.08
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition NTRK1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SH2B1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization ARHGAP32 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding ABL1 0.08
Publications: 1 Organism: Homo Sapiens