| Name | NTRK1 |
| ID | P04629 |
| Role | substrate |
| Enzymatic Domains |
LRRCT 148-193
Ig-like C2-type 1 194-283 PROSITE-ProRule
Ig-like C2-type 2 299-365 PROSITE-ProRule
Protein kinase 510-781 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | NTRK1 | Tyr681 | DIYSTDYyRVGGRTM | dephosphorylation down-regulates activity | 14662744 | SIGNOR-248469 |
| NTRK1 | NTRK1 | Tyr681 | DIYSTDYyRVGGRTM | phosphorylation up-regulates | 9099755 | SIGNOR-47179 |
| NTRK1 | NTRK1 | Tyr791 | LAQAPPVyLDVLG | phosphorylation up-regulates | 9099755 | SIGNOR-47183 |
| NTRK1 | NTRK1 | Tyr676 | FGMSRDIySTDYYRV | phosphorylation up-regulates | 9099755 | SIGNOR-47171 |
| DUSP26 | NTRK1 | – | dephosphorylation down-regulates activity | 28701747 | SIGNOR-277105 | |
| PTPN6 | NTRK1 | Tyr680 | RDIYSTDyYRVGGRT | dephosphorylation down-regulates activity | 14662744 | SIGNOR-248468 |
| NTRK1 | NTRK1 | Tyr496 | HIIENPQyFSDACVH | phosphorylation up-regulates | 9099755 | SIGNOR-47167 |
| PTPN1 | NTRK1 | – | dephosphorylation down-regulates activity | 28919207 | SIGNOR-277081 | |
| FYN | NTRK1 | – | phosphorylation up-regulates activity | 16860569 | SIGNOR-279410 | |
| NTRK1 | NTRK1 | Tyr680 | RDIYSTDyYRVGGRT | phosphorylation up-regulates | 9099755 | SIGNOR-47175 |
| SRC | NTRK1 | – | phosphorylation up-regulates activity | 20219970 | SIGNOR-279291 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | NTRK1 PTyr681 | dephosphorylation up-regulates → | NTRK1 | 14662744 | SIGNOR-248469 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr681 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47179 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr791 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47183 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr676 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47171 |
| PTPN6 | dephosphorylation down-regulates ⊣ | NTRK1 PTyr680 | dephosphorylation up-regulates → | NTRK1 | 14662744 | SIGNOR-248468 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr496 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47167 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr680 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47175 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | NTRK1 | SIGNOR-248469 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47179 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47183 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47171 |
| DUSP26 | dephosphorylation → down-regulates activity | NTRK1 | SIGNOR-277105 |
| PTPN6 | dephosphorylation → down-regulates activity | NTRK1 | SIGNOR-248468 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47167 |
| PTPN1 | dephosphorylation → down-regulates activity | NTRK1 | SIGNOR-277081 |
| FYN | phosphorylation → up-regulates activity | NTRK1 | SIGNOR-279410 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47175 |
| SRC | phosphorylation → up-regulates activity | NTRK1 | SIGNOR-279291 |