| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | NTRK1 | Tyr681 | DIYSTDYyRVGGRTM | dephosphorylation down-regulates activity | 14662744 | SIGNOR-248469 |
| NTRK1 | NTRK1 | Tyr681 | DIYSTDYyRVGGRTM | phosphorylation up-regulates | 9099755 | SIGNOR-47179 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | NTRK1 PTyr681 | dephosphorylation up-regulates → | NTRK1 | 14662744 | SIGNOR-248469 |
| NTRK1 | phosphorylation up-regulates → | NTRK1 PTyr681 | phosphorylation up-regulates → | NTRK1 | 9099755 | SIGNOR-47179 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | NTRK1 | SIGNOR-248469 |
| NTRK1 | phosphorylation → up-regulates | NTRK1 | SIGNOR-47179 |
