| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK12 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates activity | 19251701 | SIGNOR-280026 |
| ROCK1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity | 33297931 | SIGNOR-280108 |
| VRK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates activity | 16704422 | SIGNOR-280162 |
| BUB1 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates activity | 22852086 | SIGNOR-280199 |
| VRK1 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 10951572 | SIGNOR-81222 |
| CSNK1D | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 10606744 | SIGNOR-73270 |
| MAPK14 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 17535811 | SIGNOR-155246 |
| CyclinA2/CDK2 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates | 14640983 | SIGNOR-217300 |
| MAPK8 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 11896587 | SIGNOR-106538 |
| RPS6KA3 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates activity | 15867353 | SIGNOR-279567 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75645 |
| CDK9 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-145311 |
| MAPK14 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 11258706 | SIGNOR-105741 |
| CHEK2 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 10801407 | SIGNOR-77144 |
| PPP1CB | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248573 |
| SRC | TP53 | Tyr126 | AKSVTCTySPALNKM | phosphorylation down-regulates quantity by destabilization | 25071020 | SIGNOR-276668 |
| CHEK1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates activity | 15659650 | SIGNOR-217791 |
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153479 |
| DYRK1A | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 20696760 | SIGNOR-167407 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153463 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74831 |
| PRKCA | TP53 | Ser371 | AHSSHLKsKKGQSTS | phosphorylation up-regulates activity | 9571186 | SIGNOR-248999 |
| DYRK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17349958 | SIGNOR-153544 |
| AURKA | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-120836 |
| CDK7 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates | 9315650 | SIGNOR-51288 |
| PRKCD | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 16377624 | SIGNOR-143382 |
| CAK complex | TP53 | Ser371 | AHSSHLKsKKGQSTS | phosphorylation up-regulates | 9315650 | SIGNOR-269327 |
| PPP2CB | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation up-regulates quantity by stabilization | 14712210 | SIGNOR-248584 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75009 |
| STK11 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 17108107 | SIGNOR-150834 |
| MAPK14 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 15642743 | SIGNOR-226620 |
| CHEK1 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates activity | 15659650 | SIGNOR-217803 |
| PPP1CA | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248556 |
| PPP2CA | TP53 | Thr55 | DDIEQWFtEDPGPDE | dephosphorylation up-regulates quantity by stabilization | 17245430 | SIGNOR-248618 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 15870257 | SIGNOR-248319 |
| MAPKAPK5 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates | 17254968 | SIGNOR-152847 |
| CDC14A | TP53 | Ser315 | LPNNTSSsPQPKKKP | dephosphorylation down-regulates activity | 10644693 | SIGNOR-248828 |
| AURKB | TP53 | Ser215 | DRNTFRHsVVVPYEP | phosphorylation down-regulates | 22611192 | SIGNOR-197602 |
| CDK16 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation down-regulates activity | 29344296 | SIGNOR-278354 |
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 15659650 | SIGNOR-74835 |
| DAPK1 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 17339337 | SIGNOR-153491 |
| DAPK1 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17339337 | SIGNOR-153487 |
| AMPK | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 15866171 | SIGNOR-216475 |
| CDK5 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 17591690 | SIGNOR-156422 |
| CDK5 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17591690 | SIGNOR-156418 |
| TTK | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 19332559 | SIGNOR-184931 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75629 |
| MAPK11 | TP53 | – | phosphorylation up-regulates | 17254968 | SIGNOR-152843 | |
| MAPK8 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 11896587 | SIGNOR-115831 |
| SRC | TP53 | Tyr220 | RHSVVVPyEPPEVGS | phosphorylation down-regulates quantity by destabilization | 25071020 | SIGNOR-276669 |
| ATM | TP53 | Ser9 | EEPQSDPsVEPPLSQ | phosphorylation up-regulates quantity by stabilization | 11875057 | SIGNOR-115348 |
| ATM | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates quantity by stabilization | 11875057 | SIGNOR-115344 |
| PP1 | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-264670 |
| PPP1CC | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248500 |
| MAPK1 | TP53 | Thr55 | DDIEQWFtEDPGPDE | phosphorylation up-regulates activity | 15116093 | SIGNOR-279068 |
| PPP2CA | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 14712210 | SIGNOR-248619 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates quantity by destabilization | 18265945 | SIGNOR-276943 |
| MAPK13 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 10581258 | SIGNOR-72691 |
| CAK complex | TP53 | Ser376 | LKSKKGQsTSRHKKL | phosphorylation up-regulates | 9315650 | SIGNOR-269328 |
| PPP2R5C | TP53 | Thr55 | DDIEQWFtEDPGPDE | dephosphorylation up-regulates quantity by stabilization | 17245430 | SIGNOR-268154 |
| NEK10 | TP53 | Tyr327 | KKPLDGEyFTLQIRG | phosphorylation up-regulates activity | 32561851 | SIGNOR-273881 |
| MAPK14 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates activity | 10581258 | SIGNOR-72699 |
| NEK2 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation down-regulates | 30266789 | SIGNOR-278488 |
| CDK7 | TP53 | Ser376 | LKSKKGQsTSRHKKL | phosphorylation up-regulates | 9315650 | SIGNOR-51284 |
| CAK complex | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 9315650 | SIGNOR-269324 |
| PINK1 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 29033320 | SIGNOR-278418 |
| AURKB | TP53 | Ser269 | GNLLGRNsFEVRVCA | phosphorylation down-regulates | 20959462 | SIGNOR-168745 |
| CSNK2A1 | TP53 | Thr155 | DSTPPPGtRVRAMAI | phosphorylation down-regulates activity | 12628923 | SIGNOR-250968 |
| CDC14B | TP53 | Ser315 | LPNNTSSsPQPKKKP | dephosphorylation down-regulates activity | 10644693 | SIGNOR-248332 |
| PLK3 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 11447225 | SIGNOR-109239 |
| CSNK1D | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 10734067 | SIGNOR-75889 |
| ATM | TP53 | – | phosphorylation up-regulates quantity by stabilization | 17157788 | SIGNOR-151138 | |
| CHEK1 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates activity | 15659650 | SIGNOR-217799 |
| CDK1 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-84256 |
| CHEK1 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates activity | 15659650 | SIGNOR-217857 |
| SLK | TP53 | – | phosphorylation up-regulates activity | 19640899 | SIGNOR-279285 | |
| STK17A | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17339337 | SIGNOR-153532 |
| IKBKB | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 30478303 | SIGNOR-278516 |
| CAK complex | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates | 9315650 | SIGNOR-269325 |
| MAPK13 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 10581258 | SIGNOR-72687 |
| MAPK8 | TP53 | Thr81 | APAPAAPtPAAPAPA | phosphorylation up-regulates | 12531896 | SIGNOR-97405 |
| p38 | TP53 | – | phosphorylation up-regulates | 17254968 | SIGNOR-270126 | |
| DUSP26 | TP53 | Ser20 | PLSQETFsDLWKLLP | dephosphorylation down-regulates | 20562916 | SIGNOR-166258 |
| ATR | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 11865061 | SIGNOR-115134 |
| CSNK1D | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 10606744 | SIGNOR-73266 |
| AURKA | TP53 | Ser106 | SQKTYQGsYGFRLGF | phosphorylation up-regulates | 23201157 | SIGNOR-199939 |
| DUSP26 | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates | 20562916 | SIGNOR-166262 |
| EIF2AK2 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 10348343 | SIGNOR-68033 |
| MAPK14 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 10581258 | SIGNOR-72703 |
| PPP1CB | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248572 |
| CHEK2 | TP53 | Ser366 | PGGSRAHsSHLKSKK | phosphorylation up-regulates quantity by stabilization | 15659650 | SIGNOR-75633 |
| DUSP26 | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 20562916 | SIGNOR-248766 |
| CDK7 | TP53 | Ser371 | AHSSHLKsKKGQSTS | phosphorylation up-regulates | 9315650 | SIGNOR-51280 |
| MAPK8 | TP53 | – | phosphorylation up-regulates | 9724739 | SIGNOR-59812 | |
| PRKDC | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 9363941 | SIGNOR-53030 |
| CDK2 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-119379 |
| PPP1CC | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248499 |
| JNK | TP53 | – | phosphorylation up-regulates | 14699954 | SIGNOR-269985 | |
| NUAK1 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 21317932 | SIGNOR-172012 |
| CDK1 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-167779 |
| PPP2CB | TP53 | Thr55 | DDIEQWFtEDPGPDE | dephosphorylation up-regulates quantity by stabilization | 17245430 | SIGNOR-248583 |
| DAPK3 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17339337 | SIGNOR-153495 |
| ATM | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 20663147 | SIGNOR-167156 |
| ATM | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 11875057 | SIGNOR-115340 |
| MAPK9 | TP53 | Ser6 | sDPSVEPP | phosphorylation up-regulates | 17525747 | SIGNOR-155209 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 15659650 | SIGNOR-153475 |
| SMG1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 15175154 | SIGNOR-125135 |
| MAPK10 | TP53 | – | phosphorylation up-regulates | 14699954 | SIGNOR-120552 | |
| MAPK14 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 11258706 | SIGNOR-105737 |
| PRKAA1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 15866171 | SIGNOR-135960 |
| CHEK2 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 17339337 | SIGNOR-260776 |
| DUSP26 | TP53 | Ser20 | PLSQETFsDLWKLLP | dephosphorylation down-regulates activity | 20562916 | SIGNOR-248765 |
| CDK9 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates quantity by stabilization | 23603988 | SIGNOR-201931 |
| AURKB | TP53 | Thr211 | EYLDDRNtFRHSVVV | phosphorylation down-regulates | 22611192 | SIGNOR-197606 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75637 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74823 |
| MAPK9 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 11896587 | SIGNOR-115835 |
| MAPK14 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 10747897 | SIGNOR-250114 |
| DYRK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 19965871 | SIGNOR-275578 |
| AURKB | TP53 | Ser183 | CPHHERCsDSDGLAP | phosphorylation down-regulates | 22611192 | SIGNOR-197598 |
| CHEK2 | TP53 | Ser366 | PGGSRAHsSHLKSKK | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75013 |
| HIPK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17210684 | SIGNOR-151930 |
| CHUK | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 23343355 | SIGNOR-280231 |
| MAPK8 | TP53 | Thr81 | APAPAAPtPAAPAPA | phosphorylation up-regulates quantity by stabilization | 11283254 | SIGNOR-106542 |
| MAPK14 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 22975381 | SIGNOR-192057 |
| PPP1CA | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248557 |
| CDK5/CDK5R1 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 12064478 | SIGNOR-250674 |
| CAK complex | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation unknown | 9372954 | SIGNOR-269326 |
| TAF1 | TP53 | Thr55 | DDIEQWFtEDPGPDE | phosphorylation down-regulates | 15053879 | SIGNOR-123651 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates | 15870257 | SIGNOR-135980 |
| MAPK14 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates activity | 10581258 | SIGNOR-72695 |
| GRK5 | TP53 | Thr55 | DDIEQWFtEDPGPDE | phosphorylation down-regulates | 20124405 | SIGNOR-163707 |
| CSNK2A1 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 10747897 | SIGNOR-250967 |
| CDK7 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 9315650 | SIGNOR-51292 |
| ATM | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 15254178 | SIGNOR-126757 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75025 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153483 |
| CDK5 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 17591690 | SIGNOR-156414 |
| ATM | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 15254178 | SIGNOR-126753 |
| ATM | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 17967874 | SIGNOR-158636 |
| MAPK14 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10781582 | SIGNOR-226614 |
| CSNK1A1 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation unknown | 20041275 | SIGNOR-162648 |
| CDK7 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation unknown | 9372954 | SIGNOR-53311 |
| NUAK1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 21317932 | SIGNOR-172008 |
| AURKB | TP53 | Thr284 | CPGRDRRtEEENLRK | phosphorylation down-regulates | 20959462 | SIGNOR-168749 |
| MAPKAPK5 | TP53 | – | phosphorylation up-regulates | 17254968 | SIGNOR-152850 | |
| GSK3B | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates activity | 11483158 | SIGNOR-251258 |
| MAPK3 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 12955074 | SIGNOR-100270 |
| CHEK1 | TP53 | Thr387 | HKKLMFKtEGPDSD | phosphorylation up-regulates activity | 15659650 | SIGNOR-217861 |
| ATM | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 17967874 | SIGNOR-158632 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75017 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74839 |
| TP53RK | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 17712528 | SIGNOR-157471 |
| CDK9 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 23603988 | SIGNOR-201935 |
| CDK5 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17591690 | SIGNOR-156426 |
| PLK2 | TP53 | – | phosphorylation up-regulates activity | 29448085 | SIGNOR-278980 | |
| CHEK1 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 15659650 | SIGNOR-217795 |
| CyclinA2/CDK2 | TP53 | Ser392 | FKTEGPDsD | phosphorylation unknown | 10884347 | SIGNOR-250751 |
| ATM | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 20663147 | SIGNOR-167152 |
| STK11 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 17108107 | SIGNOR-150830 |
| AURKA | TP53 | Ser215 | DRNTFRHsVVVPYEP | phosphorylation down-regulates | 15469940 | SIGNOR-129809 |
| CHEK1 | TP53 | Ser366 | PGGSRAHsSHLKSKK | phosphorylation up-regulates activity | 15659650 | SIGNOR-217853 |
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75641 |
| MAPK14 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 17535811 | SIGNOR-155242 |
| CDK9 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation unknown | 16552184 | SIGNOR-145315 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK12 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 19251701 | SIGNOR-280026 |
| ROCK1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 33297931 | SIGNOR-280108 |
| VRK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 16704422 | SIGNOR-280162 |
| BUB1 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 22852086 | SIGNOR-280199 |
| VRK1 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10951572 | SIGNOR-81222 |
| CSNK1D | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10606744 | SIGNOR-73270 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17535811 | SIGNOR-155246 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 14640983 | SIGNOR-217300 |
| MAPK8 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11896587 | SIGNOR-106538 |
| RPS6KA3 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15867353 | SIGNOR-279567 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75645 |
| CDK9 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-145311 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 11258706 | SIGNOR-105741 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 10801407 | SIGNOR-77144 |
| PPP1CB | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248573 |
| SRC | phosphorylation up-regulates → | TP53 PTyr126 | phosphorylation down-regulates ⊣ | TP53 | 25071020 | SIGNOR-276668 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217791 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153479 |
| DYRK1A | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 20696760 | SIGNOR-167407 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153463 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74831 |
| PRKCA | phosphorylation up-regulates → | TP53 PSer371 | phosphorylation up-regulates → | TP53 | 9571186 | SIGNOR-248999 |
| DYRK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17349958 | SIGNOR-153544 |
| AURKA | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-120836 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51288 |
| PRKCD | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 16377624 | SIGNOR-143382 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer371 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269327 |
| PPP2CB | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation down-regulates ⊣ | TP53 | 14712210 | SIGNOR-248584 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75009 |
| STK11 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 17108107 | SIGNOR-150834 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 15642743 | SIGNOR-226620 |
| CHEK1 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217803 |
| PPP1CA | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248556 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TP53 PThr55 | dephosphorylation down-regulates ⊣ | TP53 | 17245430 | SIGNOR-248618 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 15870257 | SIGNOR-248319 |
| MAPKAPK5 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 17254968 | SIGNOR-152847 |
| CDC14A | dephosphorylation down-regulates ⊣ | TP53 PSer315 | dephosphorylation up-regulates → | TP53 | 10644693 | SIGNOR-248828 |
| AURKB | phosphorylation up-regulates → | TP53 PSer215 | phosphorylation down-regulates ⊣ | TP53 | 22611192 | SIGNOR-197602 |
| CDK16 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation down-regulates ⊣ | TP53 | 29344296 | SIGNOR-278354 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-74835 |
| DAPK1 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153491 |
| DAPK1 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153487 |
| AMPK | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15866171 | SIGNOR-216475 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156422 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156418 |
| TTK | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 19332559 | SIGNOR-184931 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75629 |
| MAPK8 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11896587 | SIGNOR-115831 |
| SRC | phosphorylation up-regulates → | TP53 PTyr220 | phosphorylation down-regulates ⊣ | TP53 | 25071020 | SIGNOR-276669 |
| ATM | phosphorylation up-regulates → | TP53 PSer9 | phosphorylation up-regulates → | TP53 | 11875057 | SIGNOR-115348 |
| ATM | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 11875057 | SIGNOR-115344 |
| PP1 | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-264670 |
| PPP1CC | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248500 |
| MAPK1 | phosphorylation up-regulates → | TP53 PThr55 | phosphorylation up-regulates → | TP53 | 15116093 | SIGNOR-279068 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 14712210 | SIGNOR-248619 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 18265945 | SIGNOR-276943 |
| MAPK13 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72691 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer376 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269328 |
| PPP2R5C | dephosphorylation down-regulates ⊣ | TP53 PThr55 | dephosphorylation down-regulates ⊣ | TP53 | 17245430 | SIGNOR-268154 |
| NEK10 | phosphorylation up-regulates → | TP53 PTyr327 | phosphorylation up-regulates → | TP53 | 32561851 | SIGNOR-273881 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72699 |
| NEK2 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation down-regulates ⊣ | TP53 | 30266789 | SIGNOR-278488 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer376 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51284 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269324 |
| PINK1 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 29033320 | SIGNOR-278418 |
| AURKB | phosphorylation up-regulates → | TP53 PSer269 | phosphorylation down-regulates ⊣ | TP53 | 20959462 | SIGNOR-168745 |
| CSNK2A1 | phosphorylation up-regulates → | TP53 PThr155 | phosphorylation down-regulates ⊣ | TP53 | 12628923 | SIGNOR-250968 |
| CDC14B | dephosphorylation down-regulates ⊣ | TP53 PSer315 | dephosphorylation up-regulates → | TP53 | 10644693 | SIGNOR-248332 |
| PLK3 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11447225 | SIGNOR-109239 |
| CSNK1D | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 10734067 | SIGNOR-75889 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217799 |
| CDK1 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-84256 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217857 |
| STK17A | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153532 |
| IKBKB | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 30478303 | SIGNOR-278516 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269325 |
| MAPK13 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72687 |
| MAPK8 | phosphorylation up-regulates → | TP53 PThr81 | phosphorylation up-regulates → | TP53 | 12531896 | SIGNOR-97405 |
| DUSP26 | dephosphorylation down-regulates ⊣ | TP53 PSer20 | dephosphorylation up-regulates → | TP53 | 20562916 | SIGNOR-166258 |
| ATR | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 11865061 | SIGNOR-115134 |
| CSNK1D | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 10606744 | SIGNOR-73266 |
| AURKA | phosphorylation up-regulates → | TP53 PSer106 | phosphorylation up-regulates → | TP53 | 23201157 | SIGNOR-199939 |
| DUSP26 | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 20562916 | SIGNOR-166262 |
| EIF2AK2 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 10348343 | SIGNOR-68033 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72703 |
| PPP1CB | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248572 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer366 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-75633 |
| DUSP26 | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 20562916 | SIGNOR-248766 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer371 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51280 |
| PRKDC | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 9363941 | SIGNOR-53030 |
| CDK2 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-119379 |
| PPP1CC | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248499 |
| NUAK1 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 21317932 | SIGNOR-172012 |
| CDK1 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-167779 |
| PPP2CB | dephosphorylation down-regulates ⊣ | TP53 PThr55 | dephosphorylation down-regulates ⊣ | TP53 | 17245430 | SIGNOR-248583 |
| DAPK3 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153495 |
| ATM | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 20663147 | SIGNOR-167156 |
| ATM | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 11875057 | SIGNOR-115340 |
| MAPK9 | phosphorylation up-regulates → | TP53 PSer6 | phosphorylation up-regulates → | TP53 | 17525747 | SIGNOR-155209 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-153475 |
| SMG1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15175154 | SIGNOR-125135 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 11258706 | SIGNOR-105737 |
| PRKAA1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15866171 | SIGNOR-135960 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-260776 |
| DUSP26 | dephosphorylation down-regulates ⊣ | TP53 PSer20 | dephosphorylation up-regulates → | TP53 | 20562916 | SIGNOR-248765 |
| CDK9 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 23603988 | SIGNOR-201931 |
| AURKB | phosphorylation up-regulates → | TP53 PThr211 | phosphorylation down-regulates ⊣ | TP53 | 22611192 | SIGNOR-197606 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75637 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74823 |
| MAPK9 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11896587 | SIGNOR-115835 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 10747897 | SIGNOR-250114 |
| DYRK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 19965871 | SIGNOR-275578 |
| AURKB | phosphorylation up-regulates → | TP53 PSer183 | phosphorylation down-regulates ⊣ | TP53 | 22611192 | SIGNOR-197598 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer366 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75013 |
| HIPK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17210684 | SIGNOR-151930 |
| CHUK | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 23343355 | SIGNOR-280231 |
| MAPK8 | phosphorylation up-regulates → | TP53 PThr81 | phosphorylation up-regulates → | TP53 | 11283254 | SIGNOR-106542 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 22975381 | SIGNOR-192057 |
| PPP1CA | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248557 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 12064478 | SIGNOR-250674 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation down-regulates ⊣ | TP53 | 9372954 | SIGNOR-269326 |
| TAF1 | phosphorylation up-regulates → | TP53 PThr55 | phosphorylation down-regulates ⊣ | TP53 | 15053879 | SIGNOR-123651 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 15870257 | SIGNOR-135980 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72695 |
| GRK5 | phosphorylation up-regulates → | TP53 PThr55 | phosphorylation down-regulates ⊣ | TP53 | 20124405 | SIGNOR-163707 |
| CSNK2A1 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 10747897 | SIGNOR-250967 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51292 |
| ATM | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 15254178 | SIGNOR-126757 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75025 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153483 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156414 |
| ATM | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15254178 | SIGNOR-126753 |
| ATM | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17967874 | SIGNOR-158636 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10781582 | SIGNOR-226614 |
| CSNK1A1 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation down-regulates ⊣ | TP53 | 20041275 | SIGNOR-162648 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation down-regulates ⊣ | TP53 | 9372954 | SIGNOR-53311 |
| NUAK1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 21317932 | SIGNOR-172008 |
| AURKB | phosphorylation up-regulates → | TP53 PThr284 | phosphorylation down-regulates ⊣ | TP53 | 20959462 | SIGNOR-168749 |
| GSK3B | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 11483158 | SIGNOR-251258 |
| MAPK3 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 12955074 | SIGNOR-100270 |
| CHEK1 | phosphorylation up-regulates → | TP53 PThr387 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217861 |
| ATM | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17967874 | SIGNOR-158632 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75017 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74839 |
| TP53RK | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17712528 | SIGNOR-157471 |
| CDK9 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 23603988 | SIGNOR-201935 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156426 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217795 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation down-regulates ⊣ | TP53 | 10884347 | SIGNOR-250751 |
| ATM | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 20663147 | SIGNOR-167152 |
| STK11 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17108107 | SIGNOR-150830 |
| AURKA | phosphorylation up-regulates → | TP53 PSer215 | phosphorylation down-regulates ⊣ | TP53 | 15469940 | SIGNOR-129809 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer366 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217853 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75641 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 17535811 | SIGNOR-155242 |
| CDK9 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation down-regulates ⊣ | TP53 | 16552184 | SIGNOR-145315 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK12 | phosphorylation → up-regulates activity | TP53 | SIGNOR-280026 |
| ROCK1 | phosphorylation → up-regulates quantity | TP53 | SIGNOR-280108 |
| VRK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-280162 |
| BUB1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-280199 |
| VRK1 | phosphorylation → up-regulates | TP53 | SIGNOR-81222 |
| CSNK1D | phosphorylation → up-regulates | TP53 | SIGNOR-73270 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-155246 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | TP53 | SIGNOR-217300 |
| MAPK8 | phosphorylation → up-regulates activity | TP53 | SIGNOR-106538 |
| RPS6KA3 | phosphorylation → up-regulates activity | TP53 | SIGNOR-279567 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75645 |
| CDK9 | phosphorylation → up-regulates activity | TP53 | SIGNOR-145311 |
| MAPK14 | phosphorylation → up-regulates | TP53 | SIGNOR-105741 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-77144 |
| PPP1CB | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248573 |
| SRC | phosphorylation down-regulates quantity by destabilization | TP53 | SIGNOR-276668 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217791 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153479 |
| DYRK1A | phosphorylation → up-regulates | TP53 | SIGNOR-167407 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153463 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74831 |
| PRKCA | phosphorylation → up-regulates activity | TP53 | SIGNOR-248999 |
| DYRK2 | phosphorylation → up-regulates | TP53 | SIGNOR-153544 |
| AURKA | phosphorylation → up-regulates activity | TP53 | SIGNOR-120836 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51288 |
| PRKCD | phosphorylation → up-regulates | TP53 | SIGNOR-143382 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269327 |
| PPP2CB | dephosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-248584 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75009 |
| STK11 | phosphorylation → up-regulates | TP53 | SIGNOR-150834 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-226620 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217803 |
| PPP1CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248556 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-248618 |
| PPM1D | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248319 |
| MAPKAPK5 | phosphorylation → up-regulates | TP53 | SIGNOR-152847 |
| CDC14A | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248828 |
| AURKB | phosphorylation down-regulates | TP53 | SIGNOR-197602 |
| CDK16 | phosphorylation → down-regulates activity | TP53 | SIGNOR-278354 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74835 |
| DAPK1 | phosphorylation → up-regulates | TP53 | SIGNOR-153491 |
| DAPK1 | phosphorylation → up-regulates | TP53 | SIGNOR-153487 |
| AMPK | phosphorylation → up-regulates | TP53 | SIGNOR-216475 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156422 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156418 |
| TTK | phosphorylation → up-regulates | TP53 | SIGNOR-184931 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75629 |
| MAPK11 | phosphorylation → up-regulates | TP53 | SIGNOR-152843 |
| MAPK8 | phosphorylation → up-regulates | TP53 | SIGNOR-115831 |
| SRC | phosphorylation down-regulates quantity by destabilization | TP53 | SIGNOR-276669 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-115348 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-115344 |
| PP1 | dephosphorylation → down-regulates activity | TP53 | SIGNOR-264670 |
| PPP1CC | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248500 |
| MAPK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-279068 |
| PPP2CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248619 |
| PPM1D | dephosphorylation down-regulates quantity by destabilization | TP53 | SIGNOR-276943 |
| MAPK13 | phosphorylation → up-regulates | TP53 | SIGNOR-72691 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269328 |
| PPP2R5C | dephosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-268154 |
| NEK10 | phosphorylation → up-regulates activity | TP53 | SIGNOR-273881 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-72699 |
| NEK2 | phosphorylation down-regulates | TP53 | SIGNOR-278488 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51284 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269324 |
| PINK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-278418 |
| AURKB | phosphorylation down-regulates | TP53 | SIGNOR-168745 |
| CSNK2A1 | phosphorylation → down-regulates activity | TP53 | SIGNOR-250968 |
| CDC14B | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248332 |
| PLK3 | phosphorylation → up-regulates activity | TP53 | SIGNOR-109239 |
| CSNK1D | phosphorylation → up-regulates | TP53 | SIGNOR-75889 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-151138 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217799 |
| CDK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-84256 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217857 |
| SLK | phosphorylation → up-regulates activity | TP53 | SIGNOR-279285 |
| STK17A | phosphorylation → up-regulates | TP53 | SIGNOR-153532 |
| IKBKB | phosphorylation → up-regulates activity | TP53 | SIGNOR-278516 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269325 |
| MAPK13 | phosphorylation → up-regulates | TP53 | SIGNOR-72687 |
| MAPK8 | phosphorylation → up-regulates | TP53 | SIGNOR-97405 |
| p38 | phosphorylation → up-regulates | TP53 | SIGNOR-270126 |
| DUSP26 | dephosphorylation down-regulates | TP53 | SIGNOR-166258 |
| ATR | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-115134 |
| CSNK1D | phosphorylation → up-regulates | TP53 | SIGNOR-73266 |
| AURKA | phosphorylation → up-regulates | TP53 | SIGNOR-199939 |
| DUSP26 | dephosphorylation down-regulates | TP53 | SIGNOR-166262 |
| EIF2AK2 | phosphorylation → up-regulates | TP53 | SIGNOR-68033 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-72703 |
| PPP1CB | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248572 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75633 |
| DUSP26 | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248766 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51280 |
| MAPK8 | phosphorylation → up-regulates | TP53 | SIGNOR-59812 |
| PRKDC | phosphorylation → up-regulates | TP53 | SIGNOR-53030 |
| CDK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-119379 |
| PPP1CC | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248499 |
| JNK | phosphorylation → up-regulates | TP53 | SIGNOR-269985 |
| NUAK1 | phosphorylation → up-regulates | TP53 | SIGNOR-172012 |
| CDK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-167779 |
| PPP2CB | dephosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-248583 |
| DAPK3 | phosphorylation → up-regulates | TP53 | SIGNOR-153495 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-167156 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-115340 |
| MAPK9 | phosphorylation → up-regulates | TP53 | SIGNOR-155209 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153475 |
| SMG1 | phosphorylation → up-regulates | TP53 | SIGNOR-125135 |
| MAPK10 | phosphorylation → up-regulates | TP53 | SIGNOR-120552 |
| MAPK14 | phosphorylation → up-regulates | TP53 | SIGNOR-105737 |
| PRKAA1 | phosphorylation → up-regulates | TP53 | SIGNOR-135960 |
| CHEK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-260776 |
| DUSP26 | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248765 |
| CDK9 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-201931 |
| AURKB | phosphorylation down-regulates | TP53 | SIGNOR-197606 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75637 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74823 |
| MAPK9 | phosphorylation → up-regulates | TP53 | SIGNOR-115835 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-250114 |
| DYRK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-275578 |
| AURKB | phosphorylation down-regulates | TP53 | SIGNOR-197598 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75013 |
| HIPK2 | phosphorylation → up-regulates | TP53 | SIGNOR-151930 |
| CHUK | phosphorylation → up-regulates activity | TP53 | SIGNOR-280231 |
| MAPK8 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-106542 |
| MAPK14 | phosphorylation → up-regulates | TP53 | SIGNOR-192057 |
| PPP1CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248557 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-250674 |
| CAK complex | phosphorylation → unknown | TP53 | SIGNOR-269326 |
| TAF1 | phosphorylation down-regulates | TP53 | SIGNOR-123651 |
| PPM1D | dephosphorylation down-regulates | TP53 | SIGNOR-135980 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-72695 |
| GRK5 | phosphorylation down-regulates | TP53 | SIGNOR-163707 |
| CSNK2A1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-250967 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51292 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-126757 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75025 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153483 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156414 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-126753 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-158636 |
| MAPK14 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-226614 |
| CSNK1A1 | phosphorylation → unknown | TP53 | SIGNOR-162648 |
| CDK7 | phosphorylation → unknown | TP53 | SIGNOR-53311 |
| NUAK1 | phosphorylation → up-regulates | TP53 | SIGNOR-172008 |
| AURKB | phosphorylation down-regulates | TP53 | SIGNOR-168749 |
| MAPKAPK5 | phosphorylation → up-regulates | TP53 | SIGNOR-152850 |
| GSK3B | phosphorylation → up-regulates activity | TP53 | SIGNOR-251258 |
| MAPK3 | phosphorylation → up-regulates | TP53 | SIGNOR-100270 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217861 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-158632 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75017 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74839 |
| TP53RK | phosphorylation → up-regulates | TP53 | SIGNOR-157471 |
| CDK9 | phosphorylation → up-regulates | TP53 | SIGNOR-201935 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156426 |
| PLK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-278980 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217795 |
| CyclinA2/CDK2 | phosphorylation → unknown | TP53 | SIGNOR-250751 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-167152 |
| STK11 | phosphorylation → up-regulates | TP53 | SIGNOR-150830 |
| AURKA | phosphorylation down-regulates | TP53 | SIGNOR-129809 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217853 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75641 |
| MAPK14 | phosphorylation → up-regulates | TP53 | SIGNOR-155242 |
| CDK9 | phosphorylation → unknown | TP53 | SIGNOR-145315 |
