Summary

Name TP53
Full Name Cellular tumor antigen p53
Synonyms Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 | P53
Primary ID P04637
Links - -
Type protein
Relations 242
Pathways Mitochondrial Control of Apoptosis, P38 Signaling, Cell cycle: G1/S phase transition, Malignant Melanoma, Acute Myeloid Leukemia, Colorectal Carcinoma, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Prostate Cancer, p53 in cancer, NPM1 in AML, AML1-ETO in AML, KIT in AML, miRNA in AML
Inhibitors seliciclib; 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide
Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png acetylation TP53 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation TP53 0.5
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png neddylation TP53 0.35
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation TP53 0.56
Publications: 2 Organism: Homo Sapiens
Pathways:p53 in cancer
+ down-regulates img/direct_inhibition.png deacetylation TP53 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.66
Publications: 10 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates img/direct-activation.png phosphorylation TP53 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.42
Publications: 6 Organism: Homo Sapiens,
Pathways:P38 Signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.72
Publications: 18 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, p53 in cancer
+ up-regulates img/direct-activation.png phosphorylation TP53 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.54
Publications: 7 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation TP53 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation TP53 0.46
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.42
Publications: 4 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ up-regulates img/direct-activation.png phosphorylation TP53 0.56
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation TP53 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53 0.49
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.5
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.37
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.47
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation TP53 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.42
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.42
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.52
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.37
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.28
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.44
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ img/unknown.png phosphorylation TP53 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.44
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.38
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.22
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TP53 0.22
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.44
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.47
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation TP53 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TP53 0.44
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation TP53 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.44
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation TP53 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png TP53 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Mitochondrial Control of Apoptosis, P38 Signaling, p53 in cancer
+ up-regulates img/direct-activation.png binding CBP/p300 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RPS6K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Proliferation 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, KIT in AML, miRNA in AML, NPM1 in AML, Colorectal Carcinoma, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer
+ up-regulates activity img/direct-activation.png binding BAX 0.32
Publications: 1 Organism: Homo Sapiens
Pathways:p53 in cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NFKB2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PMAIP1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BBC3 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/indirect-activation.png CYCS 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NDRG1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FAS 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CRYAB 0.14
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAX 0.32
Publications: 2 Organism: Homo Sapiens
Pathways:p53 in cancer
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LRBA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TNFRSF10B 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deacetylation TP53 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FASLG 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PERP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BAX 0.32
Publications: 2 Organism: Homo Sapiens
Pathways:p53 in cancer
+ down-regulates activity img/direct_inhibition.png binding ETS1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TBXAS1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png TP53 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates img/direct-activation.png binding TP53 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png TP53 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FNTA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FNTB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination TP53 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOXA1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SIAH1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AFP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.58
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates img/direct_inhibition.png binding BIRC5 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.58
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer
+ down-regulates img/direct_inhibition.png chemical inhibition TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FGF2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation THBS1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTSD 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NLRC4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OGG1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation VCAN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BIRC5 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RPS6KA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png deacetylation TP53 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MDM2 0.59
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, miRNA in AML, NPM1 in AML, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer, p53 in cancer
+ up-regulates img/direct-activation.png binding TP53 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TP53 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis, Malignant Melanoma
+ up-regulates img/direct-activation.png binding TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BID 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/direct-activation.png binding BAK1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.59
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, KIT in AML, miRNA in AML, NPM1 in AML, Colorectal Carcinoma, Mitochondrial Control of Apoptosis, Malignant Melanoma
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53 0.83
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, miRNA in AML, NPM1 in AML, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer, p53 in cancer
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, miRNA in AML, Colorectal Carcinoma, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer
+ up-regulates activity img/direct-activation.png binding TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell death 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional activation MLH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional activation PMS2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression TP53 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression DRAM2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png TP53 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png TP53 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png sumoylation TP53 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png TP53 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Malignant Melanoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation NR4A3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression TP53 0.28
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates activity img/direct_inhibition.png binding TP53 0.28
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ABCB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination TP53 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GADD45A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png TP53 0.28
Publications: 1 Organism: Homo Sapiens