Summary

Name TP53
Full Name Cellular tumor antigen p53
Synonyms Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 | P53
Primary ID P04637
Links - -
Type protein
Relations 238
Pathways Mitochondrial Control of Apoptosis, P38 Signaling, Cell cycle: G1/S phase transition, Malignant Melanoma, Acute Myeloid Leukemia, Colorectal Carcinoma, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Prostate Cancer, AML-NP1, AML1-ETO, AML-KIT, AML_miRNA
Inhibitors roscovitine; AT7519
Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png acetylation TP53 0.02
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation TP53
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png neddylation TP53
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation TP53 0.21
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png deacetylation TP53 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.01
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.06
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53 0.06
Publications: 4 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.31
Publications: 10 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation TP53 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.13
Publications: 4 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.13
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.17
Publications: 7 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.21
Publications: 18 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates img/direct-activation.png phosphorylation TP53 0.06
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.13
Publications: 6 Organism: Homo Sapiens,
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.04
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation TP53 0.01
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.03
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.01
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.04
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.13
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.03
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.13
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.08
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.04
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation TP53 0.12
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TP53 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.03
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.07
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ img/unknown.png phosphorylation TP53 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.02
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.04
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.05
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation TP53
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TP53 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TP53 0.07
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation TP53
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination TP53 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RPS6K
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown Proliferation
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO, AML-KIT, AML_miRNA, AML-NP1, Colorectal Carcinoma, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer
+ up-regulates activity img/direct-activation.png binding BAX 0.53
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BBC3
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/indirect-activation.png unknown CYCS
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ down-regulates activity img/direct_inhibition.png binding BCL2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-KIT, AML_miRNA, Colorectal Carcinoma, Mitochondrial Control of Apoptosis, Malignant Melanoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FAS 0.20
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CRYAB 0.03
Publications: 1
+ up-regulates img/indirect-activation.png unknown Apoptosis
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO, AML-KIT, AML_miRNA, AML-NP1, Colorectal Carcinoma, Mitochondrial Control of Apoptosis, Malignant Melanoma
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LRBA 0.01
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TBXAS1 0.02
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ETS1 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression TP53
Publications: 2 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML-KIT
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AFP 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.77
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition TP53
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FGF2 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png stabilization TP53 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CRYAB 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation THBS1 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTSD 0.07
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ABCB1 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HR 0.01
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.18
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NLRC4 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OGG1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation VCAN 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP2 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png unknown TP53
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.01
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png deacetylation TP53 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown TP53 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation TP53
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GADD45A 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAX 0.53
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TNFRSF10B 0.07
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PERP 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TP53
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_miRNA
+ down-regulates img/direct_inhibition.png chemical inhibition TP53
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BIRC5 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.77
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FASLG 0.09
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/direct-activation.png binding BAX 0.53
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NFKB2 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBP/p300
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BAK1 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown TP53 0.01
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination TP53 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FNTB
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FNTA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOXA1
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/direct-activation.png sumoylation TP53 0.04
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown TP53 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PMAIP1 0.05
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SIAH1 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NDRG1 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown TP53 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png unknown TP53
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Mitochondrial Control of Apoptosis, P38 Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BIRC5 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BID 0.07
Publications: 1 Organism: Mus Musculus
Pathways:Mitochondrial Control of Apoptosis
+ down-regulates activity img/direct_inhibition.png binding BCL2L1 0.19
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis, Malignant Melanoma
+ up-regulates activity img/direct-activation.png binding TP53 0.04
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis, Malignant Melanoma
+ up-regulates img/indirect-activation.png unknown TP53 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RPS6KA1 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO, AML_miRNA, AML-NP1, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MDM2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO, AML_miRNA, AML-NP1, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Luminal Breast Cancer, Malignant Melanoma, Prostate Cancer
+ up-regulates quantity by stabilization img/direct-activation.png stabilization TP53 0.01
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates quantity by stabilization img/indirect-activation.png stabilization TP53 0.62
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Malignant Melanoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation NR4A3
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TP53
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML-KIT
+ down-regulates activity img/direct_inhibition.png deacetylation TP53 0.01
Publications: 1 Organism: Mus Musculus