| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | TP53 | Ser215 | DRNTFRHsVVVPYEP | phosphorylation down-regulates | 15469940 | SIGNOR-129809 |
| AURKB | TP53 | Ser215 | DRNTFRHsVVVPYEP | phosphorylation down-regulates | 22611192 | SIGNOR-197602 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | phosphorylation up-regulates → | TP53 PSer215 | phosphorylation down-regulates ⊣ | TP53 | 15469940 | SIGNOR-129809 |
| AURKB | phosphorylation up-regulates → | TP53 PSer215 | phosphorylation down-regulates ⊣ | TP53 | 22611192 | SIGNOR-197602 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation![]() down-regulates | TP53 | SIGNOR-129809 |
| AURKB | phosphorylation![]() down-regulates | TP53 | SIGNOR-197602 |