| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates activity | 11483158 | SIGNOR-251258 |
| MAPK14 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 17535811 | SIGNOR-155242 |
| CDK9 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation unknown | 16552184 | SIGNOR-145315 |
| MAPK12 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates activity | 19251701 | SIGNOR-280026 |
| MAPK14 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 11258706 | SIGNOR-105741 |
| CDK5 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 17591690 | SIGNOR-156422 |
| MAPK14 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates activity | 10581258 | SIGNOR-72699 |
| MAPK13 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 10581258 | SIGNOR-72687 |
| MAPK14 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation up-regulates | 22975381 | SIGNOR-192057 |
| CAK complex | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation unknown | 9372954 | SIGNOR-269326 |
| CDK7 | TP53 | Ser33 | LPENNVLsPLPSQAM | phosphorylation unknown | 9372954 | SIGNOR-53311 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 11483158 | SIGNOR-251258 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 17535811 | SIGNOR-155242 |
| CDK9 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation down-regulates ⊣ | TP53 | 16552184 | SIGNOR-145315 |
| MAPK12 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 19251701 | SIGNOR-280026 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 11258706 | SIGNOR-105741 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156422 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72699 |
| MAPK13 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72687 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation up-regulates → | TP53 | 22975381 | SIGNOR-192057 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation down-regulates ⊣ | TP53 | 9372954 | SIGNOR-269326 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer33 | phosphorylation down-regulates ⊣ | TP53 | 9372954 | SIGNOR-53311 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → up-regulates activity | TP53 | SIGNOR-251258 |
| MAPK14 | phosphorylation → up-regulates | TP53 | SIGNOR-155242 |
| CDK9 | phosphorylation → unknown | TP53 | SIGNOR-145315 |
| MAPK12 | phosphorylation → up-regulates activity | TP53 | SIGNOR-280026 |
| MAPK14 | phosphorylation → up-regulates | TP53 | SIGNOR-105741 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156422 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-72699 |
| MAPK13 | phosphorylation → up-regulates | TP53 | SIGNOR-72687 |
| MAPK14 | phosphorylation → up-regulates | TP53 | SIGNOR-192057 |
| CAK complex | phosphorylation → unknown | TP53 | SIGNOR-269326 |
| CDK7 | phosphorylation → unknown | TP53 | SIGNOR-53311 |
