| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75641 |
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153479 |
| CDK7 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates | 9315650 | SIGNOR-51288 |
| CHEK2 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates quantity by stabilization | 15659650 | SIGNOR-74835 |
| CHEK1 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates activity | 15659650 | SIGNOR-217857 |
| CAK complex | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates | 9315650 | SIGNOR-269325 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75641 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153479 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51288 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-74835 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217857 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269325 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75641 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153479 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51288 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74835 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217857 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269325 |
