| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-120836 |
| CDC14A | TP53 | Ser315 | LPNNTSSsPQPKKKP | dephosphorylation down-regulates activity | 10644693 | SIGNOR-248828 |
| CDK16 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation down-regulates activity | 29344296 | SIGNOR-278354 |
| NEK2 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation down-regulates | 30266789 | SIGNOR-278488 |
| CDC14B | TP53 | Ser315 | LPNNTSSsPQPKKKP | dephosphorylation down-regulates activity | 10644693 | SIGNOR-248332 |
| CDK1 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-84256 |
| CDK2 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-119379 |
| CDK1 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-167779 |
| CDK5/CDK5R1 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 12064478 | SIGNOR-250674 |
| CyclinA2/CDK2 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates | 14640983 | SIGNOR-217300 |
| CDK9 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-145311 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-120836 |
| CDC14A | dephosphorylation down-regulates ⊣ | TP53 PSer315 | dephosphorylation up-regulates → | TP53 | 10644693 | SIGNOR-248828 |
| CDK16 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation down-regulates ⊣ | TP53 | 29344296 | SIGNOR-278354 |
| NEK2 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation down-regulates ⊣ | TP53 | 30266789 | SIGNOR-278488 |
| CDC14B | dephosphorylation down-regulates ⊣ | TP53 PSer315 | dephosphorylation up-regulates → | TP53 | 10644693 | SIGNOR-248332 |
| CDK1 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-84256 |
| CDK2 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-119379 |
| CDK1 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-167779 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 12064478 | SIGNOR-250674 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 14640983 | SIGNOR-217300 |
| CDK9 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-145311 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation → up-regulates activity | TP53 | SIGNOR-120836 |
| CDC14A | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248828 |
| CDK16 | phosphorylation → down-regulates activity | TP53 | SIGNOR-278354 |
| NEK2 | phosphorylation down-regulates | TP53 | SIGNOR-278488 |
| CDC14B | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248332 |
| CDK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-84256 |
| CDK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-119379 |
| CDK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-167779 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-250674 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | TP53 | SIGNOR-217300 |
| CDK9 | phosphorylation → up-regulates activity | TP53 | SIGNOR-145311 |
