Entity Details

Name CDK7_Ser378
ID P04637
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CHEK1TP53Ser378SKKGQSTsRHKKLMFphosphorylation
up-regulates activity		15659650SIGNOR-217857
CAK complexTP53Ser378SKKGQSTsRHKKLMFphosphorylation
up-regulates		9315650SIGNOR-269325
CHEK2TP53Ser378SKKGQSTsRHKKLMFphosphorylation
up-regulates quantity by stabilization		10710310SIGNOR-75641
CHEK2TP53Ser378SKKGQSTsRHKKLMFphosphorylation
up-regulates quantity by stabilization		17339337SIGNOR-153479
CDK7TP53Ser378SKKGQSTsRHKKLMFphosphorylation
up-regulates		9315650SIGNOR-51288
CHEK2TP53Ser378SKKGQSTsRHKKLMFphosphorylation
up-regulates quantity by stabilization		15659650SIGNOR-74835
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CHEK1phosphorylation
up-regulates
→
TP53
PSer378		phosphorylation
up-regulates
→		TP5315659650SIGNOR-217857
CAK complexphosphorylation
up-regulates
→
TP53
PSer378		phosphorylation
up-regulates
→		TP539315650SIGNOR-269325
CHEK2phosphorylation
up-regulates
→
TP53
PSer378		phosphorylation
up-regulates
→		TP5310710310SIGNOR-75641
CHEK2phosphorylation
up-regulates
→
TP53
PSer378		phosphorylation
up-regulates
→		TP5317339337SIGNOR-153479
CDK7phosphorylation
up-regulates
→
TP53
PSer378		phosphorylation
up-regulates
→		TP539315650SIGNOR-51288
CHEK2phosphorylation
up-regulates
→
TP53
PSer378		phosphorylation
up-regulates
→		TP5315659650SIGNOR-74835
Regulator Mechanism/Effect Target SIGNOR-ID
CHEK1phosphorylation
→
up-regulates activity 		TP53SIGNOR-217857
CAK complexphosphorylation
→
up-regulates 		TP53SIGNOR-269325
CHEK2phosphorylation
→
up-regulates quantity by stabilization 		TP53SIGNOR-75641
CHEK2phosphorylation
→
up-regulates quantity by stabilization 		TP53SIGNOR-153479
CDK7phosphorylation
→
up-regulates 		TP53SIGNOR-51288
CHEK2phosphorylation
→
up-regulates quantity by stabilization 		TP53SIGNOR-74835