| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75025 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153483 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74839 |
| VRK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates activity | 16704422 | SIGNOR-280162 |
| VRK1 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 10951572 | SIGNOR-81222 |
| CSNK1D | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 10606744 | SIGNOR-73270 |
| CHEK2 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75645 |
| CHEK1 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates activity | 15659650 | SIGNOR-217803 |
| DAPK1 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 17339337 | SIGNOR-153491 |
| TTK | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates | 19332559 | SIGNOR-184931 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75025 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153483 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74839 |
| VRK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 16704422 | SIGNOR-280162 |
| VRK1 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10951572 | SIGNOR-81222 |
| CSNK1D | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10606744 | SIGNOR-73270 |
| CHEK2 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75645 |
| CHEK1 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217803 |
| DAPK1 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153491 |
| TTK | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 19332559 | SIGNOR-184931 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75025 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153483 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74839 |
| VRK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-280162 |
| VRK1 | phosphorylation → up-regulates | TP53 | SIGNOR-81222 |
| CSNK1D | phosphorylation → up-regulates | TP53 | SIGNOR-73270 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75645 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217803 |
| DAPK1 | phosphorylation → up-regulates | TP53 | SIGNOR-153491 |
| TTK | phosphorylation → up-regulates | TP53 | SIGNOR-184931 |
