| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 15659650 | SIGNOR-217795 |
| MAPK8 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 11896587 | SIGNOR-106538 |
| CHEK2 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 10801407 | SIGNOR-77144 |
| DAPK1 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17339337 | SIGNOR-153487 |
| CDK5 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17591690 | SIGNOR-156418 |
| MAPK8 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 11896587 | SIGNOR-115831 |
| PLK3 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 11447225 | SIGNOR-109239 |
| CSNK1D | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 10734067 | SIGNOR-75889 |
| STK17A | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17339337 | SIGNOR-153532 |
| DUSP26 | TP53 | Ser20 | PLSQETFsDLWKLLP | dephosphorylation down-regulates | 20562916 | SIGNOR-166258 |
| CSNK1D | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 10606744 | SIGNOR-73266 |
| DAPK3 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 17339337 | SIGNOR-153495 |
| ATM | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 20663147 | SIGNOR-167156 |
| CHEK2 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 17339337 | SIGNOR-260776 |
| DUSP26 | TP53 | Ser20 | PLSQETFsDLWKLLP | dephosphorylation down-regulates activity | 20562916 | SIGNOR-248765 |
| MAPK9 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates | 11896587 | SIGNOR-115835 |
| CHUK | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 23343355 | SIGNOR-280231 |
| ATM | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 15254178 | SIGNOR-126757 |
| ATM | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates quantity by stabilization | 17967874 | SIGNOR-158636 |
| CSNK1A1 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation unknown | 20041275 | SIGNOR-162648 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217795 |
| MAPK8 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11896587 | SIGNOR-106538 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 10801407 | SIGNOR-77144 |
| DAPK1 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153487 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156418 |
| MAPK8 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11896587 | SIGNOR-115831 |
| PLK3 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11447225 | SIGNOR-109239 |
| CSNK1D | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 10734067 | SIGNOR-75889 |
| STK17A | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153532 |
| DUSP26 | dephosphorylation down-regulates ⊣ | TP53 PSer20 | dephosphorylation up-regulates → | TP53 | 20562916 | SIGNOR-166258 |
| CSNK1D | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 10606744 | SIGNOR-73266 |
| DAPK3 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153495 |
| ATM | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 20663147 | SIGNOR-167156 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-260776 |
| DUSP26 | dephosphorylation down-regulates ⊣ | TP53 PSer20 | dephosphorylation up-regulates → | TP53 | 20562916 | SIGNOR-248765 |
| MAPK9 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11896587 | SIGNOR-115835 |
| CHUK | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 23343355 | SIGNOR-280231 |
| ATM | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 15254178 | SIGNOR-126757 |
| ATM | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 17967874 | SIGNOR-158636 |
| CSNK1A1 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation down-regulates ⊣ | TP53 | 20041275 | SIGNOR-162648 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217795 |
| MAPK8 | phosphorylation → up-regulates activity | TP53 | SIGNOR-106538 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-77144 |
| DAPK1 | phosphorylation → up-regulates | TP53 | SIGNOR-153487 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156418 |
| MAPK8 | phosphorylation → up-regulates | TP53 | SIGNOR-115831 |
| PLK3 | phosphorylation → up-regulates activity | TP53 | SIGNOR-109239 |
| CSNK1D | phosphorylation → up-regulates | TP53 | SIGNOR-75889 |
| STK17A | phosphorylation → up-regulates | TP53 | SIGNOR-153532 |
| DUSP26 | dephosphorylation down-regulates | TP53 | SIGNOR-166258 |
| CSNK1D | phosphorylation → up-regulates | TP53 | SIGNOR-73266 |
| DAPK3 | phosphorylation → up-regulates | TP53 | SIGNOR-153495 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-167156 |
| CHEK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-260776 |
| DUSP26 | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248765 |
| MAPK9 | phosphorylation → up-regulates | TP53 | SIGNOR-115835 |
| CHUK | phosphorylation → up-regulates activity | TP53 | SIGNOR-280231 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-126757 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-158636 |
| CSNK1A1 | phosphorylation → unknown | TP53 | SIGNOR-162648 |
