| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 10747897 | SIGNOR-250114 |
| CSNK2A1 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 10747897 | SIGNOR-250967 |
| CDK7 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 9315650 | SIGNOR-51292 |
| CDK9 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 23603988 | SIGNOR-201935 |
| CyclinA2/CDK2 | TP53 | Ser392 | FKTEGPDsD | phosphorylation unknown | 10884347 | SIGNOR-250751 |
| STK11 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 17108107 | SIGNOR-150834 |
| CAK complex | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 9315650 | SIGNOR-269324 |
| PINK1 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 29033320 | SIGNOR-278418 |
| IKBKB | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 30478303 | SIGNOR-278516 |
| EIF2AK2 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 10348343 | SIGNOR-68033 |
| NUAK1 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 21317932 | SIGNOR-172012 |
| CDK9 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates quantity by stabilization | 23603988 | SIGNOR-201931 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 10747897 | SIGNOR-250114 |
| CSNK2A1 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 10747897 | SIGNOR-250967 |
| CDK7 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-51292 |
| CDK9 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 23603988 | SIGNOR-201935 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation down-regulates ⊣ | TP53 | 10884347 | SIGNOR-250751 |
| STK11 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 17108107 | SIGNOR-150834 |
| CAK complex | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 9315650 | SIGNOR-269324 |
| PINK1 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 29033320 | SIGNOR-278418 |
| IKBKB | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 30478303 | SIGNOR-278516 |
| EIF2AK2 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 10348343 | SIGNOR-68033 |
| NUAK1 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 21317932 | SIGNOR-172012 |
| CDK9 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 23603988 | SIGNOR-201931 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-250114 |
| CSNK2A1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-250967 |
| CDK7 | phosphorylation → up-regulates | TP53 | SIGNOR-51292 |
| CDK9 | phosphorylation → up-regulates | TP53 | SIGNOR-201935 |
| CyclinA2/CDK2 | phosphorylation → unknown | TP53 | SIGNOR-250751 |
| STK11 | phosphorylation → up-regulates | TP53 | SIGNOR-150834 |
| CAK complex | phosphorylation → up-regulates | TP53 | SIGNOR-269324 |
| PINK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-278418 |
| IKBKB | phosphorylation → up-regulates activity | TP53 | SIGNOR-278516 |
| EIF2AK2 | phosphorylation → up-regulates | TP53 | SIGNOR-68033 |
| NUAK1 | phosphorylation → up-regulates | TP53 | SIGNOR-172012 |
| CDK9 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-201931 |
