| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates quantity by stabilization | 11875057 | SIGNOR-115344 |
| MAPK13 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 10581258 | SIGNOR-72691 |
| MAPK14 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 10581258 | SIGNOR-72703 |
| DYRK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 19965871 | SIGNOR-275578 |
| HIPK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17210684 | SIGNOR-151930 |
| CDK5 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17591690 | SIGNOR-156426 |
| MAPK14 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 17535811 | SIGNOR-155246 |
| DYRK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17349958 | SIGNOR-153544 |
| PRKCD | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 16377624 | SIGNOR-143382 |
| MAPK14 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 15642743 | SIGNOR-226620 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 11875057 | SIGNOR-115344 |
| MAPK13 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72691 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72703 |
| DYRK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 19965871 | SIGNOR-275578 |
| HIPK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17210684 | SIGNOR-151930 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156426 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17535811 | SIGNOR-155246 |
| DYRK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17349958 | SIGNOR-153544 |
| PRKCD | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 16377624 | SIGNOR-143382 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 15642743 | SIGNOR-226620 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-115344 |
| MAPK13 | phosphorylation → up-regulates | TP53 | SIGNOR-72691 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-72703 |
| DYRK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-275578 |
| HIPK2 | phosphorylation → up-regulates | TP53 | SIGNOR-151930 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156426 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-155246 |
| DYRK2 | phosphorylation → up-regulates | TP53 | SIGNOR-153544 |
| PRKCD | phosphorylation → up-regulates | TP53 | SIGNOR-143382 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-226620 |
