| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK5 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates | 17254968 | SIGNOR-152847 |
| PPP1CC | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248500 |
| PPP2CA | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 14712210 | SIGNOR-248619 |
| CHEK1 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates activity | 15659650 | SIGNOR-217799 |
| DUSP26 | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates | 20562916 | SIGNOR-166262 |
| DUSP26 | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 20562916 | SIGNOR-248766 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 15659650 | SIGNOR-153475 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75637 |
| PPP1CA | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248557 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75017 |
| BUB1 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates activity | 22852086 | SIGNOR-280199 |
| PPP1CB | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248573 |
| CHEK2 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74831 |
| PPP2CB | TP53 | Ser37 | NVLSPLPsQAMDDLM | dephosphorylation up-regulates quantity by stabilization | 14712210 | SIGNOR-248584 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK5 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 17254968 | SIGNOR-152847 |
| PPP1CC | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248500 |
| PPP2CA | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 14712210 | SIGNOR-248619 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217799 |
| DUSP26 | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 20562916 | SIGNOR-166262 |
| DUSP26 | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 20562916 | SIGNOR-248766 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-153475 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75637 |
| PPP1CA | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248557 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75017 |
| BUB1 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 22852086 | SIGNOR-280199 |
| PPP1CB | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248573 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74831 |
| PPP2CB | dephosphorylation down-regulates ⊣ | TP53 PSer37 | dephosphorylation down-regulates ⊣ | TP53 | 14712210 | SIGNOR-248584 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPKAPK5 | phosphorylation → up-regulates | TP53 | SIGNOR-152847 |
| PPP1CC | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248500 |
| PPP2CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248619 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217799 |
| DUSP26 | dephosphorylation down-regulates | TP53 | SIGNOR-166262 |
| DUSP26 | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248766 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153475 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75637 |
| PPP1CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248557 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75017 |
| BUB1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-280199 |
| PPP1CB | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248573 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74831 |
| PPP2CB | dephosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-248584 |
