| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates activity | 15659650 | SIGNOR-217791 |
| DYRK1A | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 20696760 | SIGNOR-167407 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 17339337 | SIGNOR-153463 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10673501 | SIGNOR-75009 |
| PPP1CA | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248556 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 15870257 | SIGNOR-248319 |
| AMPK | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 15866171 | SIGNOR-216475 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10710310 | SIGNOR-75629 |
| PP1 | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-264670 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates quantity by destabilization | 18265945 | SIGNOR-276943 |
| ATR | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 11865061 | SIGNOR-115134 |
| PPP1CB | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248572 |
| PRKDC | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 9363941 | SIGNOR-53030 |
| PPP1CC | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates activity | 16501611 | SIGNOR-248499 |
| ATM | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 11875057 | SIGNOR-115340 |
| SMG1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 15175154 | SIGNOR-125135 |
| MAPK14 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 11258706 | SIGNOR-105737 |
| PRKAA1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 15866171 | SIGNOR-135960 |
| CHEK2 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10656682 | SIGNOR-74823 |
| PPM1D | TP53 | Ser15 | PSVEPPLsQETFSDL | dephosphorylation down-regulates | 15870257 | SIGNOR-135980 |
| MAPK14 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates activity | 10581258 | SIGNOR-72695 |
| CDK5 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 17591690 | SIGNOR-156414 |
| ATM | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 15254178 | SIGNOR-126753 |
| MAPK14 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 10781582 | SIGNOR-226614 |
| NUAK1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 21317932 | SIGNOR-172008 |
| MAPK3 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 12955074 | SIGNOR-100270 |
| ATM | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 17967874 | SIGNOR-158632 |
| TP53RK | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 17712528 | SIGNOR-157471 |
| ATM | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity by stabilization | 20663147 | SIGNOR-167152 |
| STK11 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 17108107 | SIGNOR-150830 |
| ROCK1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates quantity | 33297931 | SIGNOR-280108 |
| RPS6KA3 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates activity | 15867353 | SIGNOR-279567 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217791 |
| DYRK1A | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 20696760 | SIGNOR-167407 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17339337 | SIGNOR-153463 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10673501 | SIGNOR-75009 |
| PPP1CA | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248556 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 15870257 | SIGNOR-248319 |
| AMPK | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15866171 | SIGNOR-216475 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10710310 | SIGNOR-75629 |
| PP1 | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-264670 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 18265945 | SIGNOR-276943 |
| ATR | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 11865061 | SIGNOR-115134 |
| PPP1CB | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248572 |
| PRKDC | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 9363941 | SIGNOR-53030 |
| PPP1CC | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 16501611 | SIGNOR-248499 |
| ATM | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 11875057 | SIGNOR-115340 |
| SMG1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15175154 | SIGNOR-125135 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 11258706 | SIGNOR-105737 |
| PRKAA1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15866171 | SIGNOR-135960 |
| CHEK2 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10656682 | SIGNOR-74823 |
| PPM1D | dephosphorylation down-regulates ⊣ | TP53 PSer15 | dephosphorylation up-regulates → | TP53 | 15870257 | SIGNOR-135980 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10581258 | SIGNOR-72695 |
| CDK5 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17591690 | SIGNOR-156414 |
| ATM | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15254178 | SIGNOR-126753 |
| MAPK14 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 10781582 | SIGNOR-226614 |
| NUAK1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 21317932 | SIGNOR-172008 |
| MAPK3 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 12955074 | SIGNOR-100270 |
| ATM | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17967874 | SIGNOR-158632 |
| TP53RK | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17712528 | SIGNOR-157471 |
| ATM | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 20663147 | SIGNOR-167152 |
| STK11 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17108107 | SIGNOR-150830 |
| ROCK1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 33297931 | SIGNOR-280108 |
| RPS6KA3 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15867353 | SIGNOR-279567 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217791 |
| DYRK1A | phosphorylation → up-regulates | TP53 | SIGNOR-167407 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-153463 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75009 |
| PPP1CA | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248556 |
| PPM1D | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248319 |
| AMPK | phosphorylation → up-regulates | TP53 | SIGNOR-216475 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-75629 |
| PP1 | dephosphorylation → down-regulates activity | TP53 | SIGNOR-264670 |
| PPM1D | dephosphorylation down-regulates quantity by destabilization | TP53 | SIGNOR-276943 |
| ATR | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-115134 |
| PPP1CB | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248572 |
| PRKDC | phosphorylation → up-regulates | TP53 | SIGNOR-53030 |
| PPP1CC | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248499 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-115340 |
| SMG1 | phosphorylation → up-regulates | TP53 | SIGNOR-125135 |
| MAPK14 | phosphorylation → up-regulates | TP53 | SIGNOR-105737 |
| PRKAA1 | phosphorylation → up-regulates | TP53 | SIGNOR-135960 |
| CHEK2 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-74823 |
| PPM1D | dephosphorylation down-regulates | TP53 | SIGNOR-135980 |
| MAPK14 | phosphorylation → up-regulates activity | TP53 | SIGNOR-72695 |
| CDK5 | phosphorylation → up-regulates | TP53 | SIGNOR-156414 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-126753 |
| MAPK14 | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-226614 |
| NUAK1 | phosphorylation → up-regulates | TP53 | SIGNOR-172008 |
| MAPK3 | phosphorylation → up-regulates | TP53 | SIGNOR-100270 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-158632 |
| TP53RK | phosphorylation → up-regulates | TP53 | SIGNOR-157471 |
| ATM | phosphorylation → up-regulates quantity by stabilization | TP53 | SIGNOR-167152 |
| STK11 | phosphorylation → up-regulates | TP53 | SIGNOR-150830 |
| ROCK1 | phosphorylation → up-regulates quantity | TP53 | SIGNOR-280108 |
| RPS6KA3 | phosphorylation → up-regulates activity | TP53 | SIGNOR-279567 |
