| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates activity | 22974980 | SIGNOR-278425 |
| PRKG2 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186943 |
| AKT | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186772 |
| RPS6KB1 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186959 |
| PRKG1 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186788 |
| AKT1 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-252526 |
| MAPKAPK2 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 12367505 | SIGNOR-94025 |
| MAPKAPK3 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation unknown | 8774846 | SIGNOR-250161 |
| MAPKAPK2 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 20626350 | SIGNOR-166637 |
| AKT2 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186776 |
| AKT3 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186780 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 22974980 | SIGNOR-278425 |
| PRKG2 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186943 |
| AKT | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186772 |
| RPS6KB1 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186959 |
| PRKG1 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186788 |
| AKT1 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-252526 |
| MAPKAPK2 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 12367505 | SIGNOR-94025 |
| MAPKAPK3 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 8774846 | SIGNOR-250161 |
| MAPKAPK2 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 20626350 | SIGNOR-166637 |
| AKT2 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186776 |
| AKT3 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186780 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCD | phosphorylation → down-regulates activity | HSPB1 | SIGNOR-278425 |
| PRKG2 | phosphorylation down-regulates | HSPB1 | SIGNOR-186943 |
| AKT | phosphorylation down-regulates | HSPB1 | SIGNOR-186772 |
| RPS6KB1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186959 |
| PRKG1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186788 |
| AKT1 | phosphorylation down-regulates | HSPB1 | SIGNOR-252526 |
| MAPKAPK2 | phosphorylation down-regulates | HSPB1 | SIGNOR-94025 |
| MAPKAPK3 | phosphorylation → unknown | HSPB1 | SIGNOR-250161 |
| MAPKAPK2 | phosphorylation down-regulates | HSPB1 | SIGNOR-166637 |
| AKT2 | phosphorylation down-regulates | HSPB1 | SIGNOR-186776 |
| AKT3 | phosphorylation down-regulates | HSPB1 | SIGNOR-186780 |
