Summary

Name HSPB1
Full Name Heat shock protein beta-1
Synonyms HspB1, 28 kDa heat shock protein, Estrogen-regulated 24 kDa protein, Heat shock 27 kDa protein, HSP 27, Stress-responsive protein 27, SRP27 | HSP27, HSP28
Primary ID P04792
Links - -
Type protein
Relations 24
Function Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.17
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HSPB1
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.69
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.04
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.19
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown CASP3 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown DIABLO
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png stabilization GCH1 0.13
Publications: 1 Organism: Homo Sapiens