| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK3 | HSPB1 | Ser15 | FSLLRGPsWDPFRDW | phosphorylation unknown | 8774846 | SIGNOR-250159 |
| MAPKAPK2 | HSPB1 | Ser15 | FSLLRGPsWDPFRDW | phosphorylation down-regulates | 20626350 | SIGNOR-166629 |
| RPS6KB1 | HSPB1 | Ser15 | FSLLRGPsWDPFRDW | phosphorylation down-regulates | 19593530 | SIGNOR-186951 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPKAPK3 | phosphorylation up-regulates → | HSPB1 PSer15 | phosphorylation down-regulates ⊣ | HSPB1 | 8774846 | SIGNOR-250159 |
| MAPKAPK2 | phosphorylation up-regulates → | HSPB1 PSer15 | phosphorylation down-regulates ⊣ | HSPB1 | 20626350 | SIGNOR-166629 |
| RPS6KB1 | phosphorylation up-regulates → | HSPB1 PSer15 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186951 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPKAPK3 | phosphorylation → unknown | HSPB1 | SIGNOR-250159 |
| MAPKAPK2 | phosphorylation down-regulates | HSPB1 | SIGNOR-166629 |
| RPS6KB1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186951 |
