| Name | ITGB2 |
| ID | P05107 |
| Role | substrate |
| Enzymatic Domains |
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VWFA 124-363 UniProtKB
I-EGF 1 449-482 PROSITE-ProRule
I-EGF 2 483-535 PROSITE-ProRule
I-EGF 3 536-574 PROSITE-ProRule
I-EGF 4 575-613 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | ITGB2 | Ser745 | FEKEKLKsQWNNDNP | phosphorylation unknown | 11700305 | SIGNOR-249119 |
| PRKCD | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249124 |
| PRKCA | ITGB2 | Thr760 | LFKSATTtVMNPKFA | phosphorylation unknown | 11700305 | SIGNOR-249125 |
| SRC | ITGB2 | – | phosphorylation down-regulates activity | 25624455 | SIGNOR-254740 | |
| PRKCH | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249123 |
| PRKCD | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation up-regulates activity | 11700305 | SIGNOR-111495 |
| PRKCD | ITGB2 | Ser745 | FEKEKLKsQWNNDNP | phosphorylation unknown | 11700305 | SIGNOR-249120 |
| PRKCB | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249122 |
| JAK2 | ITGB2 | – | phosphorylation up-regulates activity | 25624455 | SIGNOR-254738 | |
| PRKCA | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249121 |
| PRKCH | ITGB2 | Ser745 | FEKEKLKsQWNNDNP | phosphorylation unknown | 11700305 | SIGNOR-249118 |
| PRKCD | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation up-regulates | 18550856 | SIGNOR-178897 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | phosphorylation up-regulates → | ITGB2 PSer745 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249119 |
| PRKCD | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249124 |
| PRKCA | phosphorylation up-regulates → | ITGB2 PThr760 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249125 |
| PRKCH | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249123 |
| PRKCD | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation up-regulates → | ITGB2 | 11700305 | SIGNOR-111495 |
| PRKCD | phosphorylation up-regulates → | ITGB2 PSer745 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249120 |
| PRKCB | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249122 |
| PRKCA | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249121 |
| PRKCH | phosphorylation up-regulates → | ITGB2 PSer745 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249118 |
| PRKCD | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation up-regulates → | ITGB2 | 18550856 | SIGNOR-178897 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCB | phosphorylation → unknown | ITGB2 | SIGNOR-249119 |
| PRKCD | phosphorylation → unknown | ITGB2 | SIGNOR-249124 |
| PRKCA | phosphorylation → unknown | ITGB2 | SIGNOR-249125 |
| SRC | phosphorylation → down-regulates activity | ITGB2 | SIGNOR-254740 |
| PRKCH | phosphorylation → unknown | ITGB2 | SIGNOR-249123 |
| PRKCD | phosphorylation → up-regulates activity | ITGB2 | SIGNOR-111495 |
| PRKCD | phosphorylation → unknown | ITGB2 | SIGNOR-249120 |
| PRKCB | phosphorylation → unknown | ITGB2 | SIGNOR-249122 |
| JAK2 | phosphorylation → up-regulates activity | ITGB2 | SIGNOR-254738 |
| PRKCA | phosphorylation → unknown | ITGB2 | SIGNOR-249121 |
| PRKCH | phosphorylation → unknown | ITGB2 | SIGNOR-249118 |
| PRKCD | phosphorylation → up-regulates | ITGB2 | SIGNOR-178897 |