Summary

Name ITGB2
Full Name Integrin beta-2
Synonyms Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta | CD18, MFI7
Primary ID P05107
Links - -
Type protein
Relations 23
Function Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation ITGB2 0.08
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ITGB2 0.08
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ITGB2 0.08
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ITGB2 0.08
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ITGB2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ITGB2 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Av/b2 integrin 0.08
Publications: 1
+ down-regulates activity img/indirect_inhibition.png dephosphorylation ITGB2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB2 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ITGB2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB2 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.08
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding AD/b2 integrin 0.08
Publications: 1
+ form complex img/form-complex.png binding AL/b2 integrin 0.08
Publications: 1
+ form complex img/form-complex.png binding AM/b2 integrin 0.08
Publications: 1
+ form complex img/form-complex.png binding AX/b2 integrin 0.08
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation ITGB2 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ITGB2 0.08
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding ITGB2 0.08
Publications: 1 Organism: Homo Sapiens