| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249121 |
| PRKCD | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation up-regulates | 18550856 | SIGNOR-178897 |
| PRKCD | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249124 |
| PRKCH | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249123 |
| PRKCD | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation up-regulates activity | 11700305 | SIGNOR-111495 |
| PRKCB | ITGB2 | Thr758 | NPLFKSAtTTVMNPK | phosphorylation unknown | 11700305 | SIGNOR-249122 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249121 |
| PRKCD | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation up-regulates → | ITGB2 | 18550856 | SIGNOR-178897 |
| PRKCD | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249124 |
| PRKCH | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249123 |
| PRKCD | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation up-regulates → | ITGB2 | 11700305 | SIGNOR-111495 |
| PRKCB | phosphorylation up-regulates → | ITGB2 PThr758 | phosphorylation down-regulates ⊣ | ITGB2 | 11700305 | SIGNOR-249122 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → unknown | ITGB2 | SIGNOR-249121 |
| PRKCD | phosphorylation → up-regulates | ITGB2 | SIGNOR-178897 |
| PRKCD | phosphorylation → unknown | ITGB2 | SIGNOR-249124 |
| PRKCH | phosphorylation → unknown | ITGB2 | SIGNOR-249123 |
| PRKCD | phosphorylation → up-regulates activity | ITGB2 | SIGNOR-111495 |
| PRKCB | phosphorylation → unknown | ITGB2 | SIGNOR-249122 |
