Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
EIF2AK2	EIF2S1	–		phosphorylation down-regulates activity	31226023	SIGNOR-260168
EIF2AK3	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates activity	25660019	SIGNOR-260874
EIF2AK4	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates activity	32513922	SIGNOR-246157
EIF2AK1	EIF2S1	Ser49	IEGMILLsELSRRRI	phosphorylation up-regulates	3352609	SIGNOR-24539
EIF2AK3	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates activity	30070006	SIGNOR-246153
EIF2AK1	EIF2S1	–		phosphorylation down-regulates activity	24714526	SIGNOR-251817
EIF2AK2	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates	16179259	SIGNOR-140656
PRKCD	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation unknown	1677563	SIGNOR-248853
EIF2AK1	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates	3352609	SIGNOR-24543
EIF2AK3	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates	17998206	SIGNOR-159160
EIF2AK3	EIF2S1	–		phosphorylation down-regulates activity	31226023	SIGNOR-260165
EIF2AK1	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation down-regulates	11041858	SIGNOR-83226
PPP1CC	EIF2S1	–		dephosphorylation up-regulates activity	27629041	SIGNOR-254119
EIF2AK1	EIF2S1	Ser49	IEGMILLsELSRRRI	phosphorylation up-regulates	10563826	SIGNOR-72152
THAP12	EIF2S1	Ser52	MILLSELsRRRIRSI	phosphorylation unknown	10542257	SIGNOR-249029

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
EIF2AK3	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	25660019	SIGNOR-260874
EIF2AK4	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	32513922	SIGNOR-246157
EIF2AK1	phosphorylation up-regulates →	EIF2S1 PSer49	phosphorylation up-regulates →	EIF2S1	3352609	SIGNOR-24539
EIF2AK3	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	30070006	SIGNOR-246153
EIF2AK2	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	16179259	SIGNOR-140656
PRKCD	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	1677563	SIGNOR-248853
EIF2AK1	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	3352609	SIGNOR-24543
EIF2AK3	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	17998206	SIGNOR-159160
EIF2AK1	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	11041858	SIGNOR-83226
EIF2AK1	phosphorylation up-regulates →	EIF2S1 PSer49	phosphorylation up-regulates →	EIF2S1	10563826	SIGNOR-72152
THAP12	phosphorylation up-regulates →	EIF2S1 PSer52	phosphorylation down-regulates ⊣	EIF2S1	10542257	SIGNOR-249029

Regulator	Mechanism/Effect	Target	SIGNOR-ID
EIF2AK2	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-260168
EIF2AK3	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-260874
EIF2AK4	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-246157
EIF2AK1	phosphorylation → up-regulates	EIF2S1	SIGNOR-24539
EIF2AK3	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-246153
EIF2AK1	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-251817
EIF2AK2	phosphorylation down-regulates	EIF2S1	SIGNOR-140656
PRKCD	phosphorylation → unknown	EIF2S1	SIGNOR-248853
EIF2AK1	phosphorylation down-regulates	EIF2S1	SIGNOR-24543
EIF2AK3	phosphorylation down-regulates	EIF2S1	SIGNOR-159160
EIF2AK3	phosphorylation → down-regulates activity	EIF2S1	SIGNOR-260165
EIF2AK1	phosphorylation down-regulates	EIF2S1	SIGNOR-83226
PPP1CC	dephosphorylation → up-regulates activity	EIF2S1	SIGNOR-254119
EIF2AK1	phosphorylation → up-regulates	EIF2S1	SIGNOR-72152
THAP12	phosphorylation → unknown	EIF2S1	SIGNOR-249029