Summary

Name EIF2S1
Full Name Eukaryotic translation initiation factor 2 subunit 1
Synonyms Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha | EIF2A
Primary ID P05198
Links - -
Type protein
Relations 29
Pathways COVID-19 Causal Network, Initiation of Translation, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
Function Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex (PubMed:16289705). In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (PubMed:16289705). EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation EIF2S1 0.886
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EIF2S1 0.756
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ img/unknown.png phosphorylation EIF2S1 0.315
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF2S1 0.912
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF2S1 0.756
Publications: 3 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ down-regulates img/direct_inhibition.png phosphorylation EIF2S1 0.715
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
+ down-regulates img/direct_inhibition.png phosphorylation EIF2S1 0.886
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EIF2S1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S1 0.793
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S1 0.825
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EIF2S1 0.257
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Ternary_GTP_eIF2_tRNA_complex 0.943
Publications: 1 Organism: Homo Sapiens
Pathways:Initiation of Translation
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S1 0.822
Publications: 1 Organism: Homo Sapiens
Pathways:Initiation of Translation
+ up-regulates activity img/direct-activation.png dephosphorylation EIF2S1 0.425
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBG2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBG1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATF4 0.628
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S1 0.862
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EIF2S1 0.254
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF2S1 0.715
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation ATF4 0.628
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF2S1 0.886
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S1 0.834
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Protein_synthesis 0.7
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Initiation of Translation, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS