| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation unknown | 1677563 | SIGNOR-248853 |
| EIF2AK1 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates | 3352609 | SIGNOR-24543 |
| EIF2AK3 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates | 17998206 | SIGNOR-159160 |
| EIF2AK1 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates | 11041858 | SIGNOR-83226 |
| THAP12 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation unknown | 10542257 | SIGNOR-249029 |
| EIF2AK3 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates activity | 25660019 | SIGNOR-260874 |
| EIF2AK4 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates activity | 32513922 | SIGNOR-246157 |
| EIF2AK3 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates activity | 30070006 | SIGNOR-246153 |
| EIF2AK2 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates | 16179259 | SIGNOR-140656 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 1677563 | SIGNOR-248853 |
| EIF2AK1 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 3352609 | SIGNOR-24543 |
| EIF2AK3 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 17998206 | SIGNOR-159160 |
| EIF2AK1 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 11041858 | SIGNOR-83226 |
| THAP12 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 10542257 | SIGNOR-249029 |
| EIF2AK3 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 25660019 | SIGNOR-260874 |
| EIF2AK4 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 32513922 | SIGNOR-246157 |
| EIF2AK3 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 30070006 | SIGNOR-246153 |
| EIF2AK2 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 16179259 | SIGNOR-140656 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCD | phosphorylation → unknown | EIF2S1 | SIGNOR-248853 |
| EIF2AK1 | phosphorylation down-regulates | EIF2S1 | SIGNOR-24543 |
| EIF2AK3 | phosphorylation down-regulates | EIF2S1 | SIGNOR-159160 |
| EIF2AK1 | phosphorylation down-regulates | EIF2S1 | SIGNOR-83226 |
| THAP12 | phosphorylation → unknown | EIF2S1 | SIGNOR-249029 |
| EIF2AK3 | phosphorylation → down-regulates activity | EIF2S1 | SIGNOR-260874 |
| EIF2AK4 | phosphorylation → down-regulates activity | EIF2S1 | SIGNOR-246157 |
| EIF2AK3 | phosphorylation → down-regulates activity | EIF2S1 | SIGNOR-246153 |
| EIF2AK2 | phosphorylation down-regulates | EIF2S1 | SIGNOR-140656 |
