| Name | JUN |
| ID | P05412 |
| Role | substrate |
| Enzymatic Domains |
bZIP 252-315 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 21561061 | SIGNOR-260758 |
| GSK3A | JUN | Ser243 | PGETPPLsPIDMESQ | phosphorylation down-regulates | 1846781 | SIGNOR-21776 |
| PAK2 | JUN | Thr89 | QSSNGHItTTPTPTQ | phosphorylation up-regulates | 21177766 | SIGNOR-170772 |
| MAPK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 12169099 | SIGNOR-91383 |
| DYRK2 | JUN | Ser243 | PGETPPLsPIDMESQ | phosphorylation down-regulates | 22307329 | SIGNOR-195771 |
| HRAS | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 1749429 | SIGNOR-236682 |
| VRK1 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 15378002 | SIGNOR-127073 |
| ABL1 | JUN | Tyr170 | LHSEPPVyANLSNFN | phosphorylation unknown | 10637231 | SIGNOR-245370 |
| CSNK2A1 | JUN | Thr231 | ALKEEPQtVPEMPGE | phosphorylation down-regulates | 1516134 | SIGNOR-19607 |
| GSK3A | JUN | Ser249 | LSPIDMEsQERIKAE | phosphorylation down-regulates | 1846781 | SIGNOR-21780 |
| ABL1 | JUN | Tyr170 | LHSEPPVyANLSNFN | phosphorylation up-regulates activity | 10637231 | SIGNOR-251428 |
| GSK3A | JUN | – | phosphorylation down-regulates | 16023596 | SIGNOR-138592 | |
| MAPK8 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 8137421 | SIGNOR-235766 |
| MAPK10 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 20395206 | SIGNOR-164804 |
| MAPK9 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 12040039 | SIGNOR-88208 |
| GSK3B | JUN | Thr239 | VPEMPGEtPPLSPID | phosphorylation down-regulates activity | 16023596 | SIGNOR-236717 |
| PBK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 26745678 | SIGNOR-278156 |
| DUSP1 | JUN | – | dephosphorylation down-regulates activity | 26734995 | SIGNOR-277102 | |
| PLK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 18650425 | SIGNOR-179555 |
| GSK3A | JUN | Thr239 | VPEMPGEtPPLSPID | phosphorylation down-regulates | 1846781 | SIGNOR-21784 |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 17158707 | SIGNOR-36466 |
| PLK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 18650425 | SIGNOR-179551 |
| PBK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 26745678 | SIGNOR-278155 |
| PLK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 17804415 | SIGNOR-157725 |
| Gbeta | JUN | – | phosphorylation up-regulates | 12169099 | SIGNOR-270033 | |
| MAPK9 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 19118012 | SIGNOR-183017 |
| VRK1 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 15378002 | SIGNOR-127069 |
| CDK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 19118012 | SIGNOR-183009 |
| HRAS | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 1749429 | SIGNOR-236686 |
| HRAS | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 12169099 | SIGNOR-235526 |
| GSK3B | JUN | Ser249 | LSPIDMEsQERIKAE | phosphorylation down-regulates activity | 1846781 | SIGNOR-18684 |
| MAPK10 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 20395206 | SIGNOR-164800 |
| MAPK15 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 12169099 | SIGNOR-91371 |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 9405416 | SIGNOR-53788 |
| MAPK9 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 12040039 | SIGNOR-88212 |
| MAPK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 12169099 | SIGNOR-91379 |
| PRKDC | JUN | Ser249 | LSPIDMEsQERIKAE | phosphorylation unknown | 8464713 | SIGNOR-248934 |
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 17158707 | SIGNOR-53784 |
| MAPK15 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 12169099 | SIGNOR-91375 |
| MAPK1 | JUN | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-201943 | |
| IKBKE | JUN | – | phosphorylation up-regulates activity | 22384232 | SIGNOR-279621 | |
| PLK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 17804415 | SIGNOR-157721 |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 12040039 | SIGNOR-236149 |
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 12040039 | SIGNOR-236130 |
| PAK2 | JUN | Thr93 | GHITTTPtPTQFLCP | phosphorylation up-regulates | 21177766 | SIGNOR-170776 |
| MAP2K4 | JUN | – | phosphorylation up-regulates activity | 10527909 | SIGNOR-279063 | |
| CDK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 19118012 | SIGNOR-183013 |
| GSK3B | JUN | Ser243 | PGETPPLsPIDMESQ | phosphorylation down-regulates activity | 16023596 | SIGNOR-235892 |
| ERK1/2 | JUN | – | phosphorylation up-regulates activity | 12509763 | SIGNOR-253214 | |
| PAK2 | JUN | Thr8 | MTAKMETtFYDDALN | phosphorylation up-regulates | 21177766 | SIGNOR-170768 |
| PAK2 | JUN | Thr286 | RLEEKVKtLKAQNSE | phosphorylation up-regulates | 21177766 | SIGNOR-170764 |
| PP2B | JUN | Ser243 | PGETPPLsPIDMESQ | dephosphorylation up-regulates | 17215518 | SIGNOR-152006 |
| MAPKAPK5 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 32690100 | SIGNOR-279422 |
| CSNK2A1 | JUN | Ser249 | LSPIDMEsQERIKAE | phosphorylation down-regulates | 1516134 | SIGNOR-19603 |
| PAK2 | JUN | Thr2 | tAKMETTF | phosphorylation up-regulates | 21177766 | SIGNOR-170760 |
| CDK6 | JUN | – | phosphorylation up-regulates quantity | 17454300 | SIGNOR-280222 | |
| ERK1/2 | JUN | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-236767 | |
| HRAS | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 12169099 | SIGNOR-235522 |
| MAPK8 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 8137421 | SIGNOR-250122 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 21561061 | SIGNOR-260758 |
| GSK3A | phosphorylation up-regulates → | JUN PSer243 | phosphorylation down-regulates ⊣ | JUN | 1846781 | SIGNOR-21776 |
| PAK2 | phosphorylation up-regulates → | JUN PThr89 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170772 |
| MAPK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-91383 |
| DYRK2 | phosphorylation up-regulates → | JUN PSer243 | phosphorylation down-regulates ⊣ | JUN | 22307329 | SIGNOR-195771 |
| HRAS | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 1749429 | SIGNOR-236682 |
| VRK1 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 15378002 | SIGNOR-127073 |
| ABL1 | phosphorylation up-regulates → | JUN PTyr170 | phosphorylation down-regulates ⊣ | JUN | 10637231 | SIGNOR-245370 |
| CSNK2A1 | phosphorylation up-regulates → | JUN PThr231 | phosphorylation down-regulates ⊣ | JUN | 1516134 | SIGNOR-19607 |
| GSK3A | phosphorylation up-regulates → | JUN PSer249 | phosphorylation down-regulates ⊣ | JUN | 1846781 | SIGNOR-21780 |
| ABL1 | phosphorylation up-regulates → | JUN PTyr170 | phosphorylation up-regulates → | JUN | 10637231 | SIGNOR-251428 |
| MAPK8 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 8137421 | SIGNOR-235766 |
| MAPK10 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 20395206 | SIGNOR-164804 |
| MAPK9 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-88208 |
| GSK3B | phosphorylation up-regulates → | JUN PThr239 | phosphorylation down-regulates ⊣ | JUN | 16023596 | SIGNOR-236717 |
| PBK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 26745678 | SIGNOR-278156 |
| PLK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 18650425 | SIGNOR-179555 |
| GSK3A | phosphorylation up-regulates → | JUN PThr239 | phosphorylation down-regulates ⊣ | JUN | 1846781 | SIGNOR-21784 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 17158707 | SIGNOR-36466 |
| PLK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 18650425 | SIGNOR-179551 |
| PBK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 26745678 | SIGNOR-278155 |
| PLK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 17804415 | SIGNOR-157725 |
| MAPK9 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 19118012 | SIGNOR-183017 |
| VRK1 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 15378002 | SIGNOR-127069 |
| CDK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 19118012 | SIGNOR-183009 |
| HRAS | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 1749429 | SIGNOR-236686 |
| HRAS | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-235526 |
| GSK3B | phosphorylation up-regulates → | JUN PSer249 | phosphorylation down-regulates ⊣ | JUN | 1846781 | SIGNOR-18684 |
| MAPK10 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 20395206 | SIGNOR-164800 |
| MAPK15 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-91371 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 9405416 | SIGNOR-53788 |
| MAPK9 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-88212 |
| MAPK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-91379 |
| PRKDC | phosphorylation up-regulates → | JUN PSer249 | phosphorylation down-regulates ⊣ | JUN | 8464713 | SIGNOR-248934 |
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 17158707 | SIGNOR-53784 |
| MAPK15 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-91375 |
| PLK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 17804415 | SIGNOR-157721 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-236149 |
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-236130 |
| PAK2 | phosphorylation up-regulates → | JUN PThr93 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170776 |
| CDK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 19118012 | SIGNOR-183013 |
| GSK3B | phosphorylation up-regulates → | JUN PSer243 | phosphorylation down-regulates ⊣ | JUN | 16023596 | SIGNOR-235892 |
| PAK2 | phosphorylation up-regulates → | JUN PThr8 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170768 |
| PAK2 | phosphorylation up-regulates → | JUN PThr286 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170764 |
| PP2B | dephosphorylation down-regulates ⊣ | JUN PSer243 | dephosphorylation down-regulates ⊣ | JUN | 17215518 | SIGNOR-152006 |
| MAPKAPK5 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 32690100 | SIGNOR-279422 |
| CSNK2A1 | phosphorylation up-regulates → | JUN PSer249 | phosphorylation down-regulates ⊣ | JUN | 1516134 | SIGNOR-19603 |
| PAK2 | phosphorylation up-regulates → | JUN PThr2 | phosphorylation up-regulates → | JUN | 21177766 | SIGNOR-170760 |
| HRAS | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-235522 |
| MAPK8 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 8137421 | SIGNOR-250122 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-260758 |
| GSK3A | phosphorylation down-regulates | JUN | SIGNOR-21776 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170772 |
| MAPK3 | phosphorylation → up-regulates | JUN | SIGNOR-91383 |
| DYRK2 | phosphorylation down-regulates | JUN | SIGNOR-195771 |
| HRAS | phosphorylation → up-regulates activity | JUN | SIGNOR-236682 |
| VRK1 | phosphorylation → up-regulates | JUN | SIGNOR-127073 |
| ABL1 | phosphorylation → unknown | JUN | SIGNOR-245370 |
| CSNK2A1 | phosphorylation down-regulates | JUN | SIGNOR-19607 |
| GSK3A | phosphorylation down-regulates | JUN | SIGNOR-21780 |
| ABL1 | phosphorylation → up-regulates activity | JUN | SIGNOR-251428 |
| GSK3A | phosphorylation down-regulates | JUN | SIGNOR-138592 |
| MAPK8 | phosphorylation → up-regulates activity | JUN | SIGNOR-235766 |
| MAPK10 | phosphorylation → up-regulates | JUN | SIGNOR-164804 |
| MAPK9 | phosphorylation → up-regulates | JUN | SIGNOR-88208 |
| GSK3B | phosphorylation → down-regulates activity | JUN | SIGNOR-236717 |
| PBK | phosphorylation → up-regulates activity | JUN | SIGNOR-278156 |
| DUSP1 | dephosphorylation → down-regulates activity | JUN | SIGNOR-277102 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-179555 |
| GSK3A | phosphorylation down-regulates | JUN | SIGNOR-21784 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-36466 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-179551 |
| PBK | phosphorylation → up-regulates activity | JUN | SIGNOR-278155 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-157725 |
| Gbeta | phosphorylation → up-regulates | JUN | SIGNOR-270033 |
| MAPK9 | phosphorylation → up-regulates | JUN | SIGNOR-183017 |
| VRK1 | phosphorylation → up-regulates | JUN | SIGNOR-127069 |
| CDK3 | phosphorylation → up-regulates | JUN | SIGNOR-183009 |
| HRAS | phosphorylation → up-regulates activity | JUN | SIGNOR-236686 |
| HRAS | phosphorylation → up-regulates activity | JUN | SIGNOR-235526 |
| GSK3B | phosphorylation → down-regulates activity | JUN | SIGNOR-18684 |
| MAPK10 | phosphorylation → up-regulates | JUN | SIGNOR-164800 |
| MAPK15 | phosphorylation → up-regulates | JUN | SIGNOR-91371 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-53788 |
| MAPK9 | phosphorylation → up-regulates | JUN | SIGNOR-88212 |
| MAPK3 | phosphorylation → up-regulates | JUN | SIGNOR-91379 |
| PRKDC | phosphorylation → unknown | JUN | SIGNOR-248934 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-53784 |
| MAPK15 | phosphorylation → up-regulates | JUN | SIGNOR-91375 |
| MAPK1 | phosphorylation → up-regulates activity | JUN | SIGNOR-201943 |
| IKBKE | phosphorylation → up-regulates activity | JUN | SIGNOR-279621 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-157721 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-236149 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-236130 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170776 |
| MAP2K4 | phosphorylation → up-regulates activity | JUN | SIGNOR-279063 |
| CDK3 | phosphorylation → up-regulates | JUN | SIGNOR-183013 |
| GSK3B | phosphorylation → down-regulates activity | JUN | SIGNOR-235892 |
| ERK1/2 | phosphorylation → up-regulates activity | JUN | SIGNOR-253214 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170768 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170764 |
| PP2B | dephosphorylation → up-regulates | JUN | SIGNOR-152006 |
| MAPKAPK5 | phosphorylation → up-regulates activity | JUN | SIGNOR-279422 |
| CSNK2A1 | phosphorylation down-regulates | JUN | SIGNOR-19603 |
| PAK2 | phosphorylation → up-regulates | JUN | SIGNOR-170760 |
| CDK6 | phosphorylation → up-regulates quantity | JUN | SIGNOR-280222 |
| ERK1/2 | phosphorylation → up-regulates activity | JUN | SIGNOR-236767 |
| HRAS | phosphorylation → up-regulates activity | JUN | SIGNOR-235522 |
| MAPK8 | phosphorylation → up-regulates activity | JUN | SIGNOR-250122 |