Summary

Name JUN
Full Name Transcription factor AP-1
Synonyms Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39
Primary ID P05412
Links - -
Type protein
Relations 103
Pathways EGFR, Insulin Receptor, SAPK/JNK Signaling, TGFbeta Signaling, WNT Signaling, WNT Signaling and Myogenesis, TNF alpha, Glioblastoma Multiforme, Luminal Breast Cancer, Glucocorticoid Receptor, AML1-ETO in AML, TFs in AML
Function Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation JUN 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation JUN 0.28
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation JUN 0.46
Publications: 3 Organism: Homo Sapiens, In Vitro
Pathways:Insulin Receptor
+ up-regulates img/direct-activation.png dephosphorylation JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation JUN 0.34
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation JUN 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.28
Publications: 4 Organism: Mus Musculus, Rattus Norvegicus
Pathways:EGFR, Insulin Receptor
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.23
Publications: 5 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates img/direct-activation.png phosphorylation JUN 0.4
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.14
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.62
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:EGFR, Glucocorticoid Receptor, SAPK/JNK Signaling, TNF alpha, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation JUN 0.51
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation JUN 0.4
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation JUN 0.28
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.14
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINA3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD4 0.35
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CFI 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding JUN 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding JUN 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:TNF alpha
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation JUN 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DDIT3 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/indirect-activation.png Proliferation 0.59
Publications: 1 Organism: Homo Sapiens
Pathways:AML1-ETO in AML, EGFR, Glioblastoma Multiforme, Luminal Breast Cancer, TNF alpha, TGFbeta Signaling, WNT Signaling
+ down-regulates activity img/indirect_inhibition.png JUN 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates img/indirect-activation.png MTHFR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RCAN1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation STAR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TGFB1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:TGFbeta Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding JUN 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:AML1-ETO in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding JUN 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding JUN 0.4
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer
+ form complex img/form-complex.png binding AP1 0.24
Publications: 4 Organism: Homo Sapiens, In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP19A1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer
+ down-regulates activity img/direct_inhibition.png binding JUN 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GOT1 0.14
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSD3B2 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SMAD3/JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates img/indirect_inhibition.png Apoptosis 0.14
Publications: 1 Organism: Mus Musculus
Pathways:AML1-ETO in AML, TNF alpha
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Monocyte differentiation 0.14
Publications: 1 Organism: Mus Musculus
Pathways:TFs in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation miR-155 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LOR 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.38
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling, TGFbeta Signaling
+ up-regulates img/indirect-activation.png JUN 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding JUN 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png JUN 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding JUN 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ form complex img/form-complex.png binding SMAD4/JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding JUN 0.28
Publications: 2 Organism: In Vitro, Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT16 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation JUN 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer
+ up-regulates img/direct-activation.png binding JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation JUN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell Migration 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling
+ up-regulates img/indirect-activation.png JUN 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TCF4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png JUN 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Brown Adipogenesis 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding SPI1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:AML1-ETO in AML, TFs in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation JUN 0.14
Publications: 1 Organism: Mus Musculus
Pathways:AML1-ETO in AML, TFs in AML