| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 8137421 | SIGNOR-250122 |
| PLK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 17804415 | SIGNOR-157725 |
| HRAS | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 1749429 | SIGNOR-236686 |
| VRK1 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 15378002 | SIGNOR-127073 |
| PBK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 26745678 | SIGNOR-278156 |
| HRAS | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 12169099 | SIGNOR-235526 |
| MAPK9 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 12040039 | SIGNOR-88212 |
| CDK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 19118012 | SIGNOR-183013 |
| MAPK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 12169099 | SIGNOR-91383 |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 9405416 | SIGNOR-53788 |
| PLK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 18650425 | SIGNOR-179555 |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 12040039 | SIGNOR-236149 |
| MAPK10 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 20395206 | SIGNOR-164804 |
| JNK | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates activity | 17158707 | SIGNOR-36466 |
| MAPK15 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 12169099 | SIGNOR-91375 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 8137421 | SIGNOR-250122 |
| PLK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 17804415 | SIGNOR-157725 |
| HRAS | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 1749429 | SIGNOR-236686 |
| VRK1 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 15378002 | SIGNOR-127073 |
| PBK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 26745678 | SIGNOR-278156 |
| HRAS | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-235526 |
| MAPK9 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-88212 |
| CDK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 19118012 | SIGNOR-183013 |
| MAPK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-91383 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 9405416 | SIGNOR-53788 |
| PLK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 18650425 | SIGNOR-179555 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-236149 |
| MAPK10 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 20395206 | SIGNOR-164804 |
| JNK | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 17158707 | SIGNOR-36466 |
| MAPK15 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-91375 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → up-regulates activity | JUN | SIGNOR-250122 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-157725 |
| HRAS | phosphorylation → up-regulates activity | JUN | SIGNOR-236686 |
| VRK1 | phosphorylation → up-regulates | JUN | SIGNOR-127073 |
| PBK | phosphorylation → up-regulates activity | JUN | SIGNOR-278156 |
| HRAS | phosphorylation → up-regulates activity | JUN | SIGNOR-235526 |
| MAPK9 | phosphorylation → up-regulates | JUN | SIGNOR-88212 |
| CDK3 | phosphorylation → up-regulates | JUN | SIGNOR-183013 |
| MAPK3 | phosphorylation → up-regulates | JUN | SIGNOR-91383 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-53788 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-179555 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-236149 |
| MAPK10 | phosphorylation → up-regulates | JUN | SIGNOR-164804 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-36466 |
| MAPK15 | phosphorylation → up-regulates | JUN | SIGNOR-91375 |
