| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 21561061 | SIGNOR-260758 |
| PBK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 26745678 | SIGNOR-278155 |
| MAPKAPK5 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 32690100 | SIGNOR-279422 |
| VRK1 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 15378002 | SIGNOR-127069 |
| MAPK15 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 12169099 | SIGNOR-91371 |
| MAPK8 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 8137421 | SIGNOR-235766 |
| MAPK9 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 12040039 | SIGNOR-88208 |
| PLK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 18650425 | SIGNOR-179551 |
| MAPK9 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 19118012 | SIGNOR-183017 |
| HRAS | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 1749429 | SIGNOR-236682 |
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 17158707 | SIGNOR-53784 |
| MAPK10 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 20395206 | SIGNOR-164800 |
| PLK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 17804415 | SIGNOR-157721 |
| HRAS | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 12169099 | SIGNOR-235522 |
| MAPK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 12169099 | SIGNOR-91379 |
| CDK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 19118012 | SIGNOR-183009 |
| JNK | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates activity | 12040039 | SIGNOR-236130 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 21561061 | SIGNOR-260758 |
| PBK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 26745678 | SIGNOR-278155 |
| MAPKAPK5 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 32690100 | SIGNOR-279422 |
| VRK1 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 15378002 | SIGNOR-127069 |
| MAPK15 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-91371 |
| MAPK8 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 8137421 | SIGNOR-235766 |
| MAPK9 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-88208 |
| PLK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 18650425 | SIGNOR-179551 |
| MAPK9 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 19118012 | SIGNOR-183017 |
| HRAS | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 1749429 | SIGNOR-236682 |
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 17158707 | SIGNOR-53784 |
| MAPK10 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 20395206 | SIGNOR-164800 |
| PLK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 17804415 | SIGNOR-157721 |
| HRAS | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-235522 |
| MAPK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12169099 | SIGNOR-91379 |
| CDK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 19118012 | SIGNOR-183009 |
| JNK | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 12040039 | SIGNOR-236130 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-260758 |
| PBK | phosphorylation → up-regulates activity | JUN | SIGNOR-278155 |
| MAPKAPK5 | phosphorylation → up-regulates activity | JUN | SIGNOR-279422 |
| VRK1 | phosphorylation → up-regulates | JUN | SIGNOR-127069 |
| MAPK15 | phosphorylation → up-regulates | JUN | SIGNOR-91371 |
| MAPK8 | phosphorylation → up-regulates activity | JUN | SIGNOR-235766 |
| MAPK9 | phosphorylation → up-regulates | JUN | SIGNOR-88208 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-179551 |
| MAPK9 | phosphorylation → up-regulates | JUN | SIGNOR-183017 |
| HRAS | phosphorylation → up-regulates activity | JUN | SIGNOR-236682 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-53784 |
| MAPK10 | phosphorylation → up-regulates | JUN | SIGNOR-164800 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-157721 |
| HRAS | phosphorylation → up-regulates activity | JUN | SIGNOR-235522 |
| MAPK3 | phosphorylation → up-regulates | JUN | SIGNOR-91379 |
| CDK3 | phosphorylation → up-regulates | JUN | SIGNOR-183009 |
| JNK | phosphorylation → up-regulates activity | JUN | SIGNOR-236130 |
