| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | JUN | Ser243 | PGETPPLsPIDMESQ | phosphorylation down-regulates | 22307329 | SIGNOR-195771 |
| GSK3A | JUN | Ser243 | PGETPPLsPIDMESQ | phosphorylation down-regulates | 1846781 | SIGNOR-21776 |
| GSK3B | JUN | Ser243 | PGETPPLsPIDMESQ | phosphorylation down-regulates activity | 16023596 | SIGNOR-235892 |
| PP2B | JUN | Ser243 | PGETPPLsPIDMESQ | dephosphorylation up-regulates | 17215518 | SIGNOR-152006 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | phosphorylation up-regulates → | JUN PSer243 | phosphorylation down-regulates ⊣ | JUN | 22307329 | SIGNOR-195771 |
| GSK3A | phosphorylation up-regulates → | JUN PSer243 | phosphorylation down-regulates ⊣ | JUN | 1846781 | SIGNOR-21776 |
| GSK3B | phosphorylation up-regulates → | JUN PSer243 | phosphorylation down-regulates ⊣ | JUN | 16023596 | SIGNOR-235892 |
| PP2B | dephosphorylation down-regulates ⊣ | JUN PSer243 | dephosphorylation down-regulates ⊣ | JUN | 17215518 | SIGNOR-152006 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK2 | phosphorylation down-regulates | JUN | SIGNOR-195771 |
| GSK3A | phosphorylation down-regulates | JUN | SIGNOR-21776 |
| GSK3B | phosphorylation → down-regulates activity | JUN | SIGNOR-235892 |
| PP2B | dephosphorylation → up-regulates | JUN | SIGNOR-152006 |
