| Name | INSR |
| ID | P06213 |
| Role | kinase |
| Enzymatic Domains |
Fibronectin type-III 1 624-726 PROSITE-ProRule
Fibronectin type-III 2 757-842 PROSITE-ProRule
Fibronectin type-III 3 853-947 PROSITE-ProRule
Protein kinase 1023-1298 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | PI3K | Tyr607 | NENTEDQySLVEDDE | phosphorylation up-regulates activity | 8385099 | SIGNOR-252693 |
| INSR | PTPN1 | Tyr66 | LHQEDNDyINASLIK | phosphorylation up-regulates activity | 11506178 | SIGNOR-249370 |
| INSR | PTEN | Tyr174 | TIPSQRRyVYYYSYL | phosphorylation down-regulates activity | 23995781 | SIGNOR-276471 |
| INSR | IRS1 | Tyr612 | TLHTDDGyMPMSPGV | phosphorylation up-regulates activity | 11416002 | SIGNOR-235971 |
| INSR | IRS2 | Tyr628 | PKVAYHPyPEDYGDI | phosphorylation down-regulates activity | 9195949 | SIGNOR-251318 |
| INSR | FABP4 | Tyr20 | SSENFDDyMKEVGVG | phosphorylation unknown | 1648089 | SIGNOR-251309 |
| INSR | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates activity | 11416002 | SIGNOR-236709 |
| INSR | SHC1 | Tyr427 | ELFDDPSyVNVQNLD | phosphorylation up-regulates activity | 11075717 | SIGNOR-251325 |
| INSR | PTEN | Tyr27 | GFDLDLTyIYPNIIA | phosphorylation down-regulates activity | 23995781 | SIGNOR-276470 |
| INSR | IRS1 | Tyr1229 | SSEDLSAyASISFQK | phosphorylation up-regulates activity | 12220227 | SIGNOR-235983 |
| INSR | CBL | Tyr700 | EGEEDTEyMTPSSRP | phosphorylation up-regulates activity | 11997497 | SIGNOR-251305 |
| INSR | INSR | Tyr1190 | DIYETDYyRKGGKGL | phosphorylation up-regulates activity | 2449432 | SIGNOR-106518 |
| INSR | KHDRBS1 | – | phosphorylation up-regulates activity | 11604231 | SIGNOR-278946 | |
| INSR | PIK3R1 | Tyr607 | NENTEDQySLVEDDE | phosphorylation up-regulates activity | 8385099 | SIGNOR-251322 |
| INSR | PIK3R3 | Tyr341 | NEDADENyFINEEDE | phosphorylation unknown | 7542745 | SIGNOR-28791 |
| INSR | GAB1 | Tyr447 | SEELDENyVPMNPNS | phosphorylation up-regulates activity | 10978177 | SIGNOR-251313 |
| INSR | FRS2 | – | phosphorylation up-regulates activity | 10650943 | SIGNOR-278945 | |
| INSR | GAB1 | Tyr589 | SHDSEENyVPMNPNL | phosphorylation up-regulates activity | 10978177 | SIGNOR-251315 |
| INSR | IRS1 | Tyr1229 | SSEDLSAyASISFQK | phosphorylation up-regulates activity | 7651388 | SIGNOR-236752 |
| INSR | PTPN1 | Tyr152 | ISEDIKSyYTVRQLE | phosphorylation up-regulates activity | 11506178 | SIGNOR-249368 |
| INSR | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates activity | 9507031 | SIGNOR-251323 |
| INSR | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates activity | 7651388 | SIGNOR-236745 |
| INSR | PI3K | Tyr580 | LRKTRDQyLMWLTQK | phosphorylation up-regulates activity | 8385099 | SIGNOR-252691 |
| INSR | CBL | Tyr774 | SENEDDGyDVPKPPV | phosphorylation up-regulates activity | 11997497 | SIGNOR-251306 |
| INSR | IRS1 | Tyr941 | EETGTEEyMKMDLGP | phosphorylation up-regulates activity | 7651388 | SIGNOR-235975 |
| INSR | GAB1 | Tyr373 | ASDTDSSyCIPTAGM | phosphorylation up-regulates activity | 10978177 | SIGNOR-251312 |
| INSR | DOK1 | Tyr398 | ARVKEEGyELPYNPA | phosphorylation up-regulates activity | 11551902 | SIGNOR-251308 |
| INSR | GAB1 | Tyr285 | TEADGELyVFNTPSG | phosphorylation up-regulates activity | 10978177 | SIGNOR-251311 |
| INSR | INSR | Tyr1361 | SYEEHIPyTHMNGGK | phosphorylation up-regulates activity | 3166375 | SIGNOR-233560 |
| INSR | CALM3 | Tyr100 | FDKDGNGyISAAELR | phosphorylation down-regulates | 3415247 | SIGNOR-266336 |
| INSR | IRS2 | Tyr632 | YHPYPEDyGDIEIGS | phosphorylation down-regulates activity | 9195949 | SIGNOR-251319 |
| INSR | BLVRA | Tyr228 | PGLKRNRyLSFHFKS | phosphorylation up-regulates activity | 15870194 | SIGNOR-275515 |
| INSR | INSR | Tyr999 | YASSNPEyLSASDVF | phosphorylation up-regulates activity | 3166375 | SIGNOR-106526 |
| INSR | IRS1 | Tyr896 | EPKSPGEyVNIEFGS | phosphorylation up-regulates activity | 12220227 | SIGNOR-236725 |
| INSR | PTPN1 | Tyr153 | SEDIKSYyTVRQLEL | phosphorylation up-regulates activity | 11506178 | SIGNOR-249369 |
| INSR | ADRB2 | Tyr132 | CVIAVDRyFAITSPF | phosphorylation down-regulates activity | 8557631 | SIGNOR-251299 |
| INSR | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates activity | 9507031 | SIGNOR-251324 |
| INSR | IRS1 | Tyr465 | GEEELSNyICMGGKG | phosphorylation up-regulates activity | 7651388 | SIGNOR-236713 |
| INSR | PTPN6 | Tyr536 | QKGQESEyGNITYPP | phosphorylation up-regulates | 7512963 | SIGNOR-26870 |
| INSR | PIK3R1 | Tyr580 | LRKTRDQyLMWLTQK | phosphorylation up-regulates activity | 8385099 | SIGNOR-251321 |
| INSR | INSR | Tyr992 | DGPLGPLyASSNPEY | phosphorylation up-regulates activity | 3166375 | SIGNOR-106522 |
| INSR | INSR | Tyr1355 | SLGFKRSyEEHIPYT | phosphorylation up-regulates activity | 3166375 | SIGNOR-22577 |
| INSR | INSR | Tyr1185 | FGMTRDIyETDYYRK | phosphorylation up-regulates activity | 2449432 | SIGNOR-106510 |
| INSR | CALM2 | Tyr100 | FDKDGNGyISAAELR | phosphorylation down-regulates | 3415247 | SIGNOR-266320 |
| INSR | GAB1 | Tyr242 | FFQQQMIyDSPPSRA | phosphorylation up-regulates activity | 10978177 | SIGNOR-251310 |
| INSR | IRS1 | Tyr612 | TLHTDDGyMPMSPGV | phosphorylation up-regulates activity | 7651388 | SIGNOR-236756 |
| INSR | GAB1 | Tyr659 | VADERVDyVVVDQQK | phosphorylation up-regulates activity | 10978177 | SIGNOR-251317 |
| INSR | PIK3R1 | Tyr368 | STKMHGDyTLTLRKG | phosphorylation up-regulates activity | 8385099 | SIGNOR-251320 |
| INSR | DOK1 | Tyr362 | DPKEDPIyDEPEGLA | phosphorylation up-regulates activity | 11551902 | SIGNOR-251307 |
| INSR | ADRB2 | Tyr350 | RRSSLKAyGNGYSSN | phosphorylation down-regulates activity | 8557631 | SIGNOR-251301 |
| INSR | ADRB2 | Tyr141 | AITSPFKyQSLLTKN | phosphorylation down-regulates activity | 8557631 | SIGNOR-251300 |
| INSR | GAB1 | Tyr472 | EPIQEANyVPMTPGT | phosphorylation up-regulates activity | 10978177 | SIGNOR-251314 |
| INSR | ADRB2 | Tyr354 | LKAYGNGySSNGNTG | phosphorylation down-regulates activity | 8557631 | SIGNOR-251302 |
| INSR | INSR | Tyr1011 | DVFPCSVyVPDEWEV | phosphorylation up-regulates activity | 3166375 | SIGNOR-233564 |
| INSR | IRS1 | Tyr632 | GRKGSGDyMPMSPKS | phosphorylation up-regulates activity | 7651388 | SIGNOR-236741 |
| INSR | IRS4 | – | phosphorylation up-regulates activity | 25905389 | SIGNOR-217897 | |
| INSR | PI3K | Tyr368 | STKMHGDyTLTLRKG | phosphorylation up-regulates activity | 8385099 | SIGNOR-252692 |
| INSR | CBL | Tyr371 | TQEQYELyCEMGSTF | phosphorylation up-regulates activity | 11997497 | SIGNOR-251304 |
| INSR | CALM1 | Tyr100 | FDKDGNGyISAAELR | phosphorylation down-regulates | 3415247 | SIGNOR-24782 |
| INSR | IRS1 | Tyr989 | VPSSRGDyMTMQMSC | phosphorylation up-regulates activity | 7651388 | SIGNOR-235979 |
| INSR | INSR | Tyr1189 | RDIYETDyYRKGGKG | phosphorylation up-regulates activity | 2449432 | SIGNOR-106514 |
| INSR | BLVRA | Tyr291 | LAEEIQKyCCSRK | phosphorylation up-regulates activity | 15870194 | SIGNOR-275516 |
| INSR | BLVRA | Tyr198 | EERKEDQyMKMTVCL | phosphorylation up-regulates activity | 15870194 | SIGNOR-275514 |
| INSR | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates activity | 10978177 | SIGNOR-251316 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | phosphorylation up-regulates → | PI3K PTyr607 | phosphorylation up-regulates → | PI3K | 8385099 | SIGNOR-252693 |
| INSR | phosphorylation up-regulates → | PTPN1 PTyr66 | phosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-249370 |
| INSR | phosphorylation up-regulates → | PTEN PTyr174 | phosphorylation down-regulates ⊣ | PTEN | 23995781 | SIGNOR-276471 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr612 | phosphorylation up-regulates → | IRS1 | 11416002 | SIGNOR-235971 |
| INSR | phosphorylation up-regulates → | IRS2 PTyr628 | phosphorylation down-regulates ⊣ | IRS2 | 9195949 | SIGNOR-251318 |
| INSR | phosphorylation up-regulates → | FABP4 PTyr20 | phosphorylation down-regulates ⊣ | FABP4 | 1648089 | SIGNOR-251309 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 11416002 | SIGNOR-236709 |
| INSR | phosphorylation up-regulates → | SHC1 PTyr427 | phosphorylation up-regulates → | SHC1 | 11075717 | SIGNOR-251325 |
| INSR | phosphorylation up-regulates → | PTEN PTyr27 | phosphorylation down-regulates ⊣ | PTEN | 23995781 | SIGNOR-276470 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr1229 | phosphorylation up-regulates → | IRS1 | 12220227 | SIGNOR-235983 |
| INSR | phosphorylation up-regulates → | CBL PTyr700 | phosphorylation up-regulates → | CBL | 11997497 | SIGNOR-251305 |
| INSR | phosphorylation up-regulates → | INSR PTyr1190 | phosphorylation up-regulates → | INSR | 2449432 | SIGNOR-106518 |
| INSR | phosphorylation up-regulates → | PIK3R1 PTyr607 | phosphorylation up-regulates → | PIK3R1 | 8385099 | SIGNOR-251322 |
| INSR | phosphorylation up-regulates → | PIK3R3 PTyr341 | phosphorylation down-regulates ⊣ | PIK3R3 | 7542745 | SIGNOR-28791 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr447 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251313 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr589 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251315 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr1229 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236752 |
| INSR | phosphorylation up-regulates → | PTPN1 PTyr152 | phosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-249368 |
| INSR | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 9507031 | SIGNOR-251323 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236745 |
| INSR | phosphorylation up-regulates → | PI3K PTyr580 | phosphorylation up-regulates → | PI3K | 8385099 | SIGNOR-252691 |
| INSR | phosphorylation up-regulates → | CBL PTyr774 | phosphorylation up-regulates → | CBL | 11997497 | SIGNOR-251306 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr941 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-235975 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr373 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251312 |
| INSR | phosphorylation up-regulates → | DOK1 PTyr398 | phosphorylation up-regulates → | DOK1 | 11551902 | SIGNOR-251308 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr285 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251311 |
| INSR | phosphorylation up-regulates → | INSR PTyr1361 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-233560 |
| INSR | phosphorylation up-regulates → | CALM3 PTyr100 | phosphorylation down-regulates ⊣ | CALM3 | 3415247 | SIGNOR-266336 |
| INSR | phosphorylation up-regulates → | IRS2 PTyr632 | phosphorylation down-regulates ⊣ | IRS2 | 9195949 | SIGNOR-251319 |
| INSR | phosphorylation up-regulates → | BLVRA PTyr228 | phosphorylation up-regulates → | BLVRA | 15870194 | SIGNOR-275515 |
| INSR | phosphorylation up-regulates → | INSR PTyr999 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-106526 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr896 | phosphorylation up-regulates → | IRS1 | 12220227 | SIGNOR-236725 |
| INSR | phosphorylation up-regulates → | PTPN1 PTyr153 | phosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-249369 |
| INSR | phosphorylation up-regulates → | ADRB2 PTyr132 | phosphorylation down-regulates ⊣ | ADRB2 | 8557631 | SIGNOR-251299 |
| INSR | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 9507031 | SIGNOR-251324 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr465 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236713 |
| INSR | phosphorylation up-regulates → | PTPN6 PTyr536 | phosphorylation up-regulates → | PTPN6 | 7512963 | SIGNOR-26870 |
| INSR | phosphorylation up-regulates → | PIK3R1 PTyr580 | phosphorylation up-regulates → | PIK3R1 | 8385099 | SIGNOR-251321 |
| INSR | phosphorylation up-regulates → | INSR PTyr992 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-106522 |
| INSR | phosphorylation up-regulates → | INSR PTyr1355 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-22577 |
| INSR | phosphorylation up-regulates → | INSR PTyr1185 | phosphorylation up-regulates → | INSR | 2449432 | SIGNOR-106510 |
| INSR | phosphorylation up-regulates → | CALM2 PTyr100 | phosphorylation down-regulates ⊣ | CALM2 | 3415247 | SIGNOR-266320 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr242 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251310 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr612 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236756 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr659 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251317 |
| INSR | phosphorylation up-regulates → | PIK3R1 PTyr368 | phosphorylation up-regulates → | PIK3R1 | 8385099 | SIGNOR-251320 |
| INSR | phosphorylation up-regulates → | DOK1 PTyr362 | phosphorylation up-regulates → | DOK1 | 11551902 | SIGNOR-251307 |
| INSR | phosphorylation up-regulates → | ADRB2 PTyr350 | phosphorylation down-regulates ⊣ | ADRB2 | 8557631 | SIGNOR-251301 |
| INSR | phosphorylation up-regulates → | ADRB2 PTyr141 | phosphorylation down-regulates ⊣ | ADRB2 | 8557631 | SIGNOR-251300 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr472 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251314 |
| INSR | phosphorylation up-regulates → | ADRB2 PTyr354 | phosphorylation down-regulates ⊣ | ADRB2 | 8557631 | SIGNOR-251302 |
| INSR | phosphorylation up-regulates → | INSR PTyr1011 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-233564 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr632 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-236741 |
| INSR | phosphorylation up-regulates → | PI3K PTyr368 | phosphorylation up-regulates → | PI3K | 8385099 | SIGNOR-252692 |
| INSR | phosphorylation up-regulates → | CBL PTyr371 | phosphorylation up-regulates → | CBL | 11997497 | SIGNOR-251304 |
| INSR | phosphorylation up-regulates → | CALM1 PTyr100 | phosphorylation down-regulates ⊣ | CALM1 | 3415247 | SIGNOR-24782 |
| INSR | phosphorylation up-regulates → | IRS1 PTyr989 | phosphorylation up-regulates → | IRS1 | 7651388 | SIGNOR-235979 |
| INSR | phosphorylation up-regulates → | INSR PTyr1189 | phosphorylation up-regulates → | INSR | 2449432 | SIGNOR-106514 |
| INSR | phosphorylation up-regulates → | BLVRA PTyr291 | phosphorylation up-regulates → | BLVRA | 15870194 | SIGNOR-275516 |
| INSR | phosphorylation up-regulates → | BLVRA PTyr198 | phosphorylation up-regulates → | BLVRA | 15870194 | SIGNOR-275514 |
| INSR | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 10978177 | SIGNOR-251316 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INSR | phosphorylation → up-regulates activity | PI3K | SIGNOR-252693 |
| INSR | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-249370 |
| INSR | phosphorylation → down-regulates activity | PTEN | SIGNOR-276471 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-235971 |
| INSR | phosphorylation → down-regulates activity | IRS2 | SIGNOR-251318 |
| INSR | phosphorylation → unknown | FABP4 | SIGNOR-251309 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236709 |
| INSR | phosphorylation → up-regulates activity | SHC1 | SIGNOR-251325 |
| INSR | phosphorylation → down-regulates activity | PTEN | SIGNOR-276470 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-235983 |
| INSR | phosphorylation → up-regulates activity | CBL | SIGNOR-251305 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106518 |
| INSR | phosphorylation → up-regulates activity | KHDRBS1 | SIGNOR-278946 |
| INSR | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-251322 |
| INSR | phosphorylation → unknown | PIK3R3 | SIGNOR-28791 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251313 |
| INSR | phosphorylation → up-regulates activity | FRS2 | SIGNOR-278945 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251315 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236752 |
| INSR | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-249368 |
| INSR | phosphorylation → up-regulates activity | PTK2 | SIGNOR-251323 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236745 |
| INSR | phosphorylation → up-regulates activity | PI3K | SIGNOR-252691 |
| INSR | phosphorylation → up-regulates activity | CBL | SIGNOR-251306 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-235975 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251312 |
| INSR | phosphorylation → up-regulates activity | DOK1 | SIGNOR-251308 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251311 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-233560 |
| INSR | phosphorylation down-regulates | CALM3 | SIGNOR-266336 |
| INSR | phosphorylation → down-regulates activity | IRS2 | SIGNOR-251319 |
| INSR | phosphorylation → up-regulates activity | BLVRA | SIGNOR-275515 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106526 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236725 |
| INSR | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-249369 |
| INSR | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-251299 |
| INSR | phosphorylation → up-regulates activity | PTK2 | SIGNOR-251324 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236713 |
| INSR | phosphorylation → up-regulates | PTPN6 | SIGNOR-26870 |
| INSR | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-251321 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106522 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-22577 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106510 |
| INSR | phosphorylation down-regulates | CALM2 | SIGNOR-266320 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251310 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236756 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251317 |
| INSR | phosphorylation → up-regulates activity | PIK3R1 | SIGNOR-251320 |
| INSR | phosphorylation → up-regulates activity | DOK1 | SIGNOR-251307 |
| INSR | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-251301 |
| INSR | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-251300 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251314 |
| INSR | phosphorylation → down-regulates activity | ADRB2 | SIGNOR-251302 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-233564 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-236741 |
| INSR | phosphorylation → up-regulates activity | IRS4 | SIGNOR-217897 |
| INSR | phosphorylation → up-regulates activity | PI3K | SIGNOR-252692 |
| INSR | phosphorylation → up-regulates activity | CBL | SIGNOR-251304 |
| INSR | phosphorylation down-regulates | CALM1 | SIGNOR-24782 |
| INSR | phosphorylation → up-regulates activity | IRS1 | SIGNOR-235979 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106514 |
| INSR | phosphorylation → up-regulates activity | BLVRA | SIGNOR-275516 |
| INSR | phosphorylation → up-regulates activity | BLVRA | SIGNOR-275514 |
| INSR | phosphorylation → up-regulates activity | GAB1 | SIGNOR-251316 |