Summary

Name INSR
Full Name Insulin receptor
Synonyms IR
Primary ID P06213
Links - -
Type protein
Relations 153
Pathways Adipogenesis, AMPK Signaling, FAP: In vitro induction of adipogenesis, FAP: Insulin-mediated adipogenesis, FAP: INSR, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling, Pericyte: In vitro induction of adipogenesis
Inhibitors 2-[[2-[[1-[2-(dimethylamino)-1-oxoethyl]-5-methoxy-2,3-dihydroindol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide; N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide; Linsitinib; BMS-554417; 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-pyridinone; NVP-AEW541; BMS-754807
Function Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation INSR 0.354
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CALM3 0.384
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM1 0.413
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM2 0.359
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation INSR 0.2
Publications: 8 Organism: In Vitro
Pathways:Adipogenesis, AMPK Signaling, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.559
Publications: 8 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.309
Publications: 8 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation INSR 0.774
Publications: 6 Organism: Homo Sapiens, Mus Musculus
Pathways:Insulin Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.384
Publications: 9 Organism: Homo Sapiens, In Vitro
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.349
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation INSR 0.29
Publications: 4 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.365
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.263
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.273
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.597
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation INSR 0.263
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation INSR 0.373
Publications: 3 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation INSR 0.597
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.911
Publications: 11 Organism: Homo Sapiens, Cricetulus Griseus, Rattus Norvegicus
Pathways:Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation ADRB2 0.385
Publications: 4 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.774
Publications: 3 Organism: In Vitro
Pathways:Insulin Signaling
+ up-regulates activity img/direct-activation.png phosphorylation BLVRA 0.5
Publications: 3
+ img/unknown.png phosphorylation FABP4 0.4
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.49
Publications: 8 Organism: Mus Musculus
+ img/unknown.png phosphorylation PIK3R3 0.609
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ up-regulates activity img/direct-activation.png phosphorylation DOK1 0.537
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation PI3K 0.599
Publications: 3 Organism: Chlorocebus Aethiops
Pathways:FAP: Insulin-mediated adipogenesis, Leptin Signaling, mTOR in cancer
+ up-regulates activity img/direct-activation.png phosphorylation PIK3R1 0.653
Publications: 3 Organism: Chlorocebus Aethiops
Pathways:MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.5
Publications: 3 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.696
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation PTPN6 0.365
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTK2 0.36
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS2 0.747
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding INSR 0.6
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png binding INSR 0.708
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png DOK4 0.378
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ down-regulates img/direct_inhibition.png chemical inhibition INSR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png DOK5 0.383
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ up-regulates img/direct-activation.png phosphorylation INSR 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:AMPK Signaling, Leptin Signaling, MTOR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition INSR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB7 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding INSR 0.932
Publications: 2 Organism: Homo Sapiens, Cricetulus Griseus
Pathways:Adipogenesis, AMPK Signaling, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ up-regulates img/direct-activation.png binding IRS2 0.747
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png chemical inhibition INSR 0.8
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation IRS4 0.499
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding SHC1 0.696
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding INSR 0.398
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding INSR 0.643
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding INSR 0.746
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition INSR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation INSR 0.38
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png chemical inhibition INSR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination INSR 0.5
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage INSR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition INSR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition INSR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage INSR 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png GYS1 0.377
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Insulin Signaling