| Name | INSR |
| ID | P06213 |
| Role | substrate |
| Enzymatic Domains |
Fibronectin type-III 1 624-726 PROSITE-ProRule
Fibronectin type-III 2 757-842 PROSITE-ProRule
Fibronectin type-III 3 853-947 PROSITE-ProRule
Protein kinase 1023-1298 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 1715686 | SIGNOR-21307 |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 22124607 | SIGNOR-276947 |
| PTPRH | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76084 |
| INSR | INSR | Tyr1361 | SYEEHIPyTHMNGGK | phosphorylation up-regulates activity | 3166375 | SIGNOR-233560 |
| PTPN1 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 22124607 | SIGNOR-276946 |
| PTPRB | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75993 |
| PTPRH | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76072 |
| PTPN9 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 16679294 | SIGNOR-146668 |
| PTPN12 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 8454633 | SIGNOR-39147 |
| PRKAA2 | INSR | – | phosphorylation up-regulates | 22207502 | SIGNOR-195324 | |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 16582879 | SIGNOR-248409 |
| PTPRJ | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 1715686 | SIGNOR-21299 |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 11579209 | SIGNOR-235499 |
| PTPN6 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-75934 |
| PTPRH | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76076 |
| PTPRG | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254703 |
| PTPN2 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 1373652 | SIGNOR-18018 |
| PTPRH | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-76080 |
| PTPRG | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254705 |
| PTPN1 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 11579209 | SIGNOR-235503 |
| PTPRB | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75989 |
| PTPN13 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 15611135 | SIGNOR-132559 |
| PTPN12 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-75902 |
| AMPK | INSR | – | phosphorylation up-regulates | 22207502 | SIGNOR-216619 | |
| PTPN12 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 8454633 | SIGNOR-39159 |
| PTPN6 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75926 |
| PTPRJ | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76100 |
| PTPN2 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 12612081 | SIGNOR-248386 |
| MTOR | INSR | – | phosphorylation up-regulates activity | 26584640 | SIGNOR-280045 | |
| PTPRF | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 1303753 | SIGNOR-16239 |
| PTPN2 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75910 |
| PTPRF | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-76013 |
| PTPN13 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 15611135 | SIGNOR-132555 |
| INSR | INSR | Tyr1011 | DVFPCSVyVPDEWEV | phosphorylation up-regulates activity | 3166375 | SIGNOR-233564 |
| PTPRF | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 1303753 | SIGNOR-16247 |
| PTPRF | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76009 |
| PTPRG | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254704 |
| PRKCA | INSR | Ser1064 | KTVNESAsLRERIEF | phosphorylation unknown | 7926007 | SIGNOR-248906 |
| PTPRJ | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 1715686 | SIGNOR-21303 |
| PTPN12 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-262291 |
| PTPN2 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 30230471 | SIGNOR-276957 |
| INSR | INSR | Tyr1190 | DIYETDYyRKGGKGL | phosphorylation up-regulates activity | 2449432 | SIGNOR-106518 |
| PTPRF | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76017 |
| PRKCA | INSR | Thr1362 | YEEHIPYtHMNGGKK | phosphorylation unknown | 8463287 | SIGNOR-248933 |
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75914 |
| PTPN9 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 16679294 | SIGNOR-146680 |
| PTPRE | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 15738637 | SIGNOR-248446 |
| PTPN12 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 8454633 | SIGNOR-39151 |
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 30230471 | SIGNOR-276956 |
| PTPN12 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75898 |
| PTPN13 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 15611135 | SIGNOR-132563 |
| PTPRB | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-75997 |
| PTPRJ | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76088 |
| PTPN9 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 16679294 | SIGNOR-146672 |
| PTPRB | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76001 |
| PTPN9 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 16679294 | SIGNOR-146676 |
| PTPN12 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-75906 |
| PTPN6 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75930 |
| INSR | INSR | Tyr992 | DGPLGPLyASSNPEY | phosphorylation up-regulates activity | 3166375 | SIGNOR-106522 |
| PTPN1 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates activity | 16582879 | SIGNOR-248408 |
| PTPRF | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76005 |
| PTPN1 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates activity | 11579209 | SIGNOR-235495 |
| PTPN2 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-75922 |
| PTPN1 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 16582879 | SIGNOR-248410 |
| INSR | INSR | Tyr999 | YASSNPEyLSASDVF | phosphorylation up-regulates activity | 3166375 | SIGNOR-106526 |
| PTPRJ | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-76096 |
| PTPN6 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-75938 |
| PTPN12 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75894 |
| PTPRJ | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 1715686 | SIGNOR-21295 |
| PRKCA | INSR | Ser1062 | AVKTVNEsASLRERI | phosphorylation unknown | 7926007 | SIGNOR-248905 |
| PTPRJ | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76092 |
| INSR | INSR | Tyr1355 | SLGFKRSyEEHIPYT | phosphorylation up-regulates activity | 3166375 | SIGNOR-22577 |
| PTPRF | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 1303753 | SIGNOR-16235 |
| PTPN12 | INSR | – | dephosphorylation down-regulates | 8454633 | SIGNOR-39155 | |
| PTPN2 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-75918 |
| INSR | INSR | Tyr1185 | FGMTRDIyETDYYRK | phosphorylation up-regulates activity | 2449432 | SIGNOR-106510 |
| PTPRE | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates activity | 15738637 | SIGNOR-248443 |
| PTPRE | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 15738637 | SIGNOR-248445 |
| PTPRE | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates activity | 15738637 | SIGNOR-248444 |
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 12612081 | SIGNOR-248385 |
| INSR | INSR | Tyr1189 | RDIYETDyYRKGGKG | phosphorylation up-regulates activity | 2449432 | SIGNOR-106514 |
| PTPRF | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 1303753 | SIGNOR-16243 |
| PTPN13 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 15611135 | SIGNOR-132551 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21307 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 22124607 | SIGNOR-276947 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76084 |
| INSR | phosphorylation up-regulates → | INSR PTyr1361 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-233560 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 22124607 | SIGNOR-276946 |
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75993 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76072 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146668 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 8454633 | SIGNOR-39147 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 16582879 | SIGNOR-248409 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21299 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 11579209 | SIGNOR-235499 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75934 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76076 |
| PTPRG | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation down-regulates ⊣ | INSR | 25624455 | SIGNOR-254703 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 1373652 | SIGNOR-18018 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76080 |
| PTPRG | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation down-regulates ⊣ | INSR | 25624455 | SIGNOR-254705 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 11579209 | SIGNOR-235503 |
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75989 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132559 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75902 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 8454633 | SIGNOR-39159 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75926 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76100 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 12612081 | SIGNOR-248386 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16239 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75910 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76013 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132555 |
| INSR | phosphorylation up-regulates → | INSR PTyr1011 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-233564 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16247 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76009 |
| PTPRG | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation down-regulates ⊣ | INSR | 25624455 | SIGNOR-254704 |
| PRKCA | phosphorylation up-regulates → | INSR PSer1064 | phosphorylation down-regulates ⊣ | INSR | 7926007 | SIGNOR-248906 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21303 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-262291 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 30230471 | SIGNOR-276957 |
| INSR | phosphorylation up-regulates → | INSR PTyr1190 | phosphorylation up-regulates → | INSR | 2449432 | SIGNOR-106518 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76017 |
| PRKCA | phosphorylation up-regulates → | INSR PThr1362 | phosphorylation down-regulates ⊣ | INSR | 8463287 | SIGNOR-248933 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75914 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146680 |
| PTPRE | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 15738637 | SIGNOR-248446 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 8454633 | SIGNOR-39151 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 30230471 | SIGNOR-276956 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75898 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132563 |
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75997 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76088 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146672 |
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76001 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146676 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75906 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75930 |
| INSR | phosphorylation up-regulates → | INSR PTyr992 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-106522 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 16582879 | SIGNOR-248408 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76005 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 11579209 | SIGNOR-235495 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75922 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 16582879 | SIGNOR-248410 |
| INSR | phosphorylation up-regulates → | INSR PTyr999 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-106526 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76096 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75938 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75894 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21295 |
| PRKCA | phosphorylation up-regulates → | INSR PSer1062 | phosphorylation down-regulates ⊣ | INSR | 7926007 | SIGNOR-248905 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76092 |
| INSR | phosphorylation up-regulates → | INSR PTyr1355 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-22577 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16235 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75918 |
| INSR | phosphorylation up-regulates → | INSR PTyr1185 | phosphorylation up-regulates → | INSR | 2449432 | SIGNOR-106510 |
| PTPRE | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 15738637 | SIGNOR-248443 |
| PTPRE | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 15738637 | SIGNOR-248445 |
| PTPRE | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 15738637 | SIGNOR-248444 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 12612081 | SIGNOR-248385 |
| INSR | phosphorylation up-regulates → | INSR PTyr1189 | phosphorylation up-regulates → | INSR | 2449432 | SIGNOR-106514 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16243 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132551 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21307 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276947 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76084 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-233560 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276946 |
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-75993 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76072 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146668 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-39147 |
| PRKAA2 | phosphorylation → up-regulates | INSR | SIGNOR-195324 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248409 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21299 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-235499 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75934 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76076 |
| PTPRG | dephosphorylation → up-regulates activity | INSR | SIGNOR-254703 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-18018 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76080 |
| PTPRG | dephosphorylation → up-regulates activity | INSR | SIGNOR-254705 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-235503 |
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-75989 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132559 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-75902 |
| AMPK | phosphorylation → up-regulates | INSR | SIGNOR-216619 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-39159 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75926 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76100 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248386 |
| MTOR | phosphorylation → up-regulates activity | INSR | SIGNOR-280045 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16239 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75910 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76013 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132555 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-233564 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16247 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76009 |
| PTPRG | dephosphorylation → up-regulates activity | INSR | SIGNOR-254704 |
| PRKCA | phosphorylation → unknown | INSR | SIGNOR-248906 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21303 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-262291 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276957 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106518 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76017 |
| PRKCA | phosphorylation → unknown | INSR | SIGNOR-248933 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75914 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146680 |
| PTPRE | dephosphorylation → down-regulates activity | INSR | SIGNOR-248446 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-39151 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276956 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-75898 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132563 |
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-75997 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76088 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146672 |
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-76001 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146676 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-75906 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75930 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106522 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248408 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76005 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-235495 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75922 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248410 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106526 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76096 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75938 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-75894 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21295 |
| PRKCA | phosphorylation → unknown | INSR | SIGNOR-248905 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76092 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-22577 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16235 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-39155 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75918 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106510 |
| PTPRE | dephosphorylation → down-regulates activity | INSR | SIGNOR-248443 |
| PTPRE | dephosphorylation → down-regulates activity | INSR | SIGNOR-248445 |
| PTPRE | dephosphorylation → down-regulates activity | INSR | SIGNOR-248444 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248385 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106514 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16243 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132551 |