| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRB | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75989 |
| PTPRF | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 1303753 | SIGNOR-16235 |
| PTPRH | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76072 |
| INSR | INSR | Tyr1185 | FGMTRDIyETDYYRK | phosphorylation up-regulates activity | 2449432 | SIGNOR-106510 |
| PTPN6 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75926 |
| PTPRJ | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76088 |
| PTPRJ | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 1715686 | SIGNOR-21295 |
| PTPRE | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates activity | 15738637 | SIGNOR-248444 |
| PTPN12 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75894 |
| PTPN1 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates activity | 11579209 | SIGNOR-235495 |
| PTPRF | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76005 |
| PTPN12 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 8454633 | SIGNOR-39147 |
| PTPN2 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75910 |
| PTPN1 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates activity | 16582879 | SIGNOR-248408 |
| PTPN9 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 16679294 | SIGNOR-146668 |
| PTPN13 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 15611135 | SIGNOR-132551 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75989 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16235 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76072 |
| INSR | phosphorylation up-regulates → | INSR PTyr1185 | phosphorylation up-regulates → | INSR | 2449432 | SIGNOR-106510 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75926 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76088 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21295 |
| PTPRE | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 15738637 | SIGNOR-248444 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75894 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 11579209 | SIGNOR-235495 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76005 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 8454633 | SIGNOR-39147 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75910 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 16582879 | SIGNOR-248408 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146668 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132551 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-75989 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16235 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76072 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106510 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75926 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76088 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21295 |
| PTPRE | dephosphorylation → down-regulates activity | INSR | SIGNOR-248444 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-75894 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-235495 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76005 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-39147 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75910 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248408 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146668 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132551 |
