| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 30230471 | SIGNOR-276956 |
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 12612081 | SIGNOR-248385 |
| INSR | INSR | Tyr1189 | RDIYETDyYRKGGKG | phosphorylation up-regulates activity | 2449432 | SIGNOR-106514 |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 11579209 | SIGNOR-235499 |
| PTPN12 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75898 |
| PTPN9 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 16679294 | SIGNOR-146672 |
| PTPRB | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75993 |
| PTPRH | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76076 |
| PTPRF | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76009 |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 22124607 | SIGNOR-276947 |
| PTPRE | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 15738637 | SIGNOR-248445 |
| PTPRG | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254704 |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 16582879 | SIGNOR-248409 |
| PTPRJ | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76092 |
| PTPRF | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 1303753 | SIGNOR-16239 |
| PTPN13 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 15611135 | SIGNOR-132555 |
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75914 |
| PTPN6 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75930 |
| PTPRJ | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 1715686 | SIGNOR-21299 |
| PTPN12 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 8454633 | SIGNOR-39151 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 30230471 | SIGNOR-276956 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 12612081 | SIGNOR-248385 |
| INSR | phosphorylation up-regulates → | INSR PTyr1189 | phosphorylation up-regulates → | INSR | 2449432 | SIGNOR-106514 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 11579209 | SIGNOR-235499 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75898 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146672 |
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75993 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76076 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76009 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 22124607 | SIGNOR-276947 |
| PTPRE | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 15738637 | SIGNOR-248445 |
| PTPRG | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation down-regulates ⊣ | INSR | 25624455 | SIGNOR-254704 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 16582879 | SIGNOR-248409 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76092 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16239 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132555 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75914 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75930 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21299 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 8454633 | SIGNOR-39151 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276956 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248385 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106514 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-235499 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-75898 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146672 |
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-75993 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76076 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76009 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276947 |
| PTPRE | dephosphorylation → down-regulates activity | INSR | SIGNOR-248445 |
| PTPRG | dephosphorylation → up-regulates activity | INSR | SIGNOR-254704 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248409 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76092 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16239 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132555 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75914 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75930 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21299 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-39151 |
