| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRB | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76001 |
| PTPN2 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-75922 |
| PTPRF | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 1303753 | SIGNOR-16247 |
| PTPRH | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76084 |
| INSR | INSR | Tyr999 | YASSNPEyLSASDVF | phosphorylation up-regulates activity | 3166375 | SIGNOR-106526 |
| PTPRE | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates activity | 15738637 | SIGNOR-248443 |
| PTPN12 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-75906 |
| PTPRJ | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76100 |
| PTPN12 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 8454633 | SIGNOR-39159 |
| PTPN6 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-75938 |
| PTPN9 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 16679294 | SIGNOR-146680 |
| PTPRF | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76017 |
| PTPN13 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 15611135 | SIGNOR-132563 |
| PTPRJ | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 1715686 | SIGNOR-21307 |
| PTPRG | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254703 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRB | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76001 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75922 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16247 |
| PTPRH | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76084 |
| INSR | phosphorylation up-regulates → | INSR PTyr999 | phosphorylation up-regulates → | INSR | 3166375 | SIGNOR-106526 |
| PTPRE | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 15738637 | SIGNOR-248443 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75906 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76100 |
| PTPN12 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 8454633 | SIGNOR-39159 |
| PTPN6 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75938 |
| PTPN9 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 16679294 | SIGNOR-146680 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76017 |
| PTPN13 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 15611135 | SIGNOR-132563 |
| PTPRJ | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 1715686 | SIGNOR-21307 |
| PTPRG | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation down-regulates ⊣ | INSR | 25624455 | SIGNOR-254703 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRB | dephosphorylation down-regulates | INSR | SIGNOR-76001 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75922 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16247 |
| PTPRH | dephosphorylation down-regulates | INSR | SIGNOR-76084 |
| INSR | phosphorylation → up-regulates activity | INSR | SIGNOR-106526 |
| PTPRE | dephosphorylation → down-regulates activity | INSR | SIGNOR-248443 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-75906 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-76100 |
| PTPN12 | dephosphorylation down-regulates | INSR | SIGNOR-39159 |
| PTPN6 | dephosphorylation down-regulates | INSR | SIGNOR-75938 |
| PTPN9 | dephosphorylation down-regulates | INSR | SIGNOR-146680 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76017 |
| PTPN13 | dephosphorylation down-regulates | INSR | SIGNOR-132563 |
| PTPRJ | dephosphorylation down-regulates | INSR | SIGNOR-21307 |
| PTPRG | dephosphorylation → up-regulates activity | INSR | SIGNOR-254703 |
