| Name | FYN |
| ID | P06241 |
| Role | substrate |
| Enzymatic Domains |
SH3 82-143 PROSITE-ProRule
SH2 149-246 PROSITE-ProRule
Protein kinase 271-524 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | FYN | Tyr420 | RLIEDNEyTARQGAK | phosphorylation up-regulates | 22080863 | SIGNOR-177109 |
| PTPN2 | FYN | Tyr420 | RLIEDNEyTARQGAK | dephosphorylation down-regulates | 22080863 | SIGNOR-177113 |
| FYN | FYN | Tyr30 | NQSSGYRyGTDPTPQ | phosphorylation up-regulates activity | 9425276 | SIGNOR-251165 |
| PTPRA | FYN | Tyr531 | FTATEPQyQPGENL | dephosphorylation up-regulates | 17507376 | SIGNOR-154796 |
| PDGFRB | FYN | Tyr28 | SLNQSSGyRYGTDPT | phosphorylation up-regulates activity | 9425276 | SIGNOR-250253 |
| PTPRA | FYN | Tyr531 | FTATEPQyQPGENL | dephosphorylation up-regulates activity | 9535845 | SIGNOR-248435 |
| SMO | FYN | – | phosphorylation up-regulates | 18455992 | SIGNOR-178607 | |
| PRKACA | FYN | Ser21 | LTEERDGsLNQSSGY | phosphorylation up-regulates | 20658524 | SIGNOR-167147 |
| FYN | FYN | Tyr420 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 9425276 | SIGNOR-251167 |
| PTPN5 | FYN | Tyr420 | RLIEDNEyTARQGAK | dephosphorylation down-regulates | 11983687 | SIGNOR-86791 |
| PTPRF | FYN | Tyr420 | RLIEDNEyTARQGAK | dephosphorylation down-regulates | 12496362 | SIGNOR-96768 |
| PTPRF | FYN | Tyr531 | FTATEPQyQPGENL | dephosphorylation up-regulates | 12496362 | SIGNOR-96764 |
| PTPRC | FYN | Tyr531 | FTATEPQyQPGENL | dephosphorylation up-regulates activity | 11909961 | SIGNOR-248352 |
| FYN | FYN | Tyr28 | SLNQSSGyRYGTDPT | phosphorylation up-regulates activity | 9425276 | SIGNOR-251168 |
| FYN | FYN | Tyr39 | TDPTPQHyPSFGVTS | phosphorylation up-regulates activity | 9425276 | SIGNOR-251166 |
| SMO | FYN | – | phosphorylation up-regulates | 23074268 | SIGNOR-199156 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | phosphorylation up-regulates → | FYN PTyr420 | phosphorylation up-regulates → | FYN | 22080863 | SIGNOR-177109 |
| PTPN2 | dephosphorylation down-regulates ⊣ | FYN PTyr420 | dephosphorylation up-regulates → | FYN | 22080863 | SIGNOR-177113 |
| FYN | phosphorylation up-regulates → | FYN PTyr30 | phosphorylation up-regulates → | FYN | 9425276 | SIGNOR-251165 |
| PTPRA | dephosphorylation down-regulates ⊣ | FYN PTyr531 | dephosphorylation down-regulates ⊣ | FYN | 17507376 | SIGNOR-154796 |
| PDGFRB | phosphorylation up-regulates → | FYN PTyr28 | phosphorylation up-regulates → | FYN | 9425276 | SIGNOR-250253 |
| PTPRA | dephosphorylation down-regulates ⊣ | FYN PTyr531 | dephosphorylation down-regulates ⊣ | FYN | 9535845 | SIGNOR-248435 |
| PRKACA | phosphorylation up-regulates → | FYN PSer21 | phosphorylation up-regulates → | FYN | 20658524 | SIGNOR-167147 |
| FYN | phosphorylation up-regulates → | FYN PTyr420 | phosphorylation up-regulates → | FYN | 9425276 | SIGNOR-251167 |
| PTPN5 | dephosphorylation down-regulates ⊣ | FYN PTyr420 | dephosphorylation up-regulates → | FYN | 11983687 | SIGNOR-86791 |
| PTPRF | dephosphorylation down-regulates ⊣ | FYN PTyr420 | dephosphorylation up-regulates → | FYN | 12496362 | SIGNOR-96768 |
| PTPRF | dephosphorylation down-regulates ⊣ | FYN PTyr531 | dephosphorylation down-regulates ⊣ | FYN | 12496362 | SIGNOR-96764 |
| PTPRC | dephosphorylation down-regulates ⊣ | FYN PTyr531 | dephosphorylation down-regulates ⊣ | FYN | 11909961 | SIGNOR-248352 |
| FYN | phosphorylation up-regulates → | FYN PTyr28 | phosphorylation up-regulates → | FYN | 9425276 | SIGNOR-251168 |
| FYN | phosphorylation up-regulates → | FYN PTyr39 | phosphorylation up-regulates → | FYN | 9425276 | SIGNOR-251166 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FYN | phosphorylation → up-regulates | FYN | SIGNOR-177109 |
| PTPN2 | dephosphorylation down-regulates | FYN | SIGNOR-177113 |
| FYN | phosphorylation → up-regulates activity | FYN | SIGNOR-251165 |
| PTPRA | dephosphorylation → up-regulates | FYN | SIGNOR-154796 |
| PDGFRB | phosphorylation → up-regulates activity | FYN | SIGNOR-250253 |
| PTPRA | dephosphorylation → up-regulates activity | FYN | SIGNOR-248435 |
| SMO | phosphorylation → up-regulates | FYN | SIGNOR-178607 |
| PRKACA | phosphorylation → up-regulates | FYN | SIGNOR-167147 |
| FYN | phosphorylation → up-regulates activity | FYN | SIGNOR-251167 |
| PTPN5 | dephosphorylation down-regulates | FYN | SIGNOR-86791 |
| PTPRF | dephosphorylation down-regulates | FYN | SIGNOR-96768 |
| PTPRF | dephosphorylation → up-regulates | FYN | SIGNOR-96764 |
| PTPRC | dephosphorylation → up-regulates activity | FYN | SIGNOR-248352 |
| FYN | phosphorylation → up-regulates activity | FYN | SIGNOR-251168 |
| FYN | phosphorylation → up-regulates activity | FYN | SIGNOR-251166 |
| SMO | phosphorylation → up-regulates | FYN | SIGNOR-199156 |