Summary

Name FYN
Full Name Tyrosine-protein kinase Fyn
Synonyms Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, SLK, p59-Fyn
Primary ID P06241
Links - -
Type protein
Relations 116
Pathways B-cell activation, Mitochondrial dynamics in T cell exhaustion, T cell activation
Function Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FYN 0.429
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AGAP2 0.44
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRIN2B 0.76
Publications: 8 Organism: In Vitro, Homo Sapiens,
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2A 0.724
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation DCC 0.551
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation ACP1 0.391
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation GRIN2A 0.724
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CAV1 0.709
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BSG (isoform 2) 0.274
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.842
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.76
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation SCN5A 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDK5 0.586
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPT 0.557
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NMT1 0.391
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CNN1 0.338
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation CD300LB 0.317
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation CD79B 0.658
Publications: 2 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation CD79A 0.575
Publications: 1 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates quantity img/direct-activation.png phosphorylation IFITM3 0.467
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation LAT 0.737
Publications: 2 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CTLA4 0.761
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHN2 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CTLA4 0.761
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CD300LF 0.354
Publications: 2
+ down-regulates activity img/direct_inhibition.png phosphorylation CNN3 0.338
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation TRIO 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FYN 0.2
Publications: 4 Organism: In Vitro
Pathways:B-cell activation, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation FYN 0.557
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SLAMF1 0.645
Publications: 3 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation FCGR2A 0.508
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation WAS 0.584
Publications: 1 Organism: Mus Musculus
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation FCGR2C 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAPK14 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CLIC5 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DLG2 0.378
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.719
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ITPR1 0.499
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGAP33 0.475
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation FYN 0.405
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation FYN 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITCH 0.374
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation TXK 0.354
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation FYN 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ down-regulates img/direct_inhibition.png dephosphorylation FYN 0.547
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ img/unknown.png phosphorylation CD5 0.509
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TOM1L1 0.447
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PGD 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLG4 0.585
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.332
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation FYN 0.405
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation FYN 0.641
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation FYN 0.719
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png dephosphorylation FYN 0.641
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation JUP 0.536
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation JUP 0.536
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation DCBLD2 0.357
Publications: 7 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FYB1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TGFB1I1 0.35
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation KIRREL1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAG 0.438
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation MED28 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GRB10 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.801
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.551
Publications: 2 Organism: In Vitro
Pathways:B-cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPRT 0.429
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Dl 0.616
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/direct-activation.png binding FYN 0.557
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ up-regulates img/direct-activation.png binding FYN 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FYN 0.399
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Mk 0.616
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation PTPRF 0.405
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Ml 0.616
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/direct-activation.png phosphorylation PRKCQ 0.351
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LCP2 0.744
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ img/unknown.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VAV1 0.616
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Dk 0.616
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation