Summary

Name FYN
Full Name Tyrosine-protein kinase Fyn
Synonyms Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, SLK, p59-Fyn
Primary ID P06241
Links - -
Type protein
Relations 131
Pathways B-cell activation, Mitochondrial dynamics in T cell exhaustion, T cell activation
Function Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FYN 0.456
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AGAP2 0.465
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRIN2B 0.767
Publications: 8 Organism: In Vitro, Homo Sapiens,
+ up-regulates activity img/direct-activation.png phosphorylation KCND3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2A 0.733
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation DCC 0.57
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPRJ 0.367
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ACP1 0.383
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation GRIN2A 0.733
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CAV1 0.72
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BSG (isoform 2) 0.27
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.851
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.767
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation SCN5A 0.294
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDK5 0.606
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPT 0.537
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NMT1 0.383
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CNN1 0.334
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation CD300LB 0.31
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation CD79B 0.671
Publications: 2 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation CD79A 0.594
Publications: 1 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates quantity img/direct-activation.png phosphorylation IFITM3 0.454
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation LAT 0.748
Publications: 2 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CTLA4 0.77
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHN2 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CTLA4 0.77
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CD300LF 0.344
Publications: 2
+ down-regulates activity img/direct_inhibition.png phosphorylation CNN3 0.334
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.328
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TRIO 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FYN 0.579
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FYN 0.2
Publications: 4 Organism: In Vitro
Pathways:B-cell activation, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation SLAMF1 0.657
Publications: 3 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation FCGR2A 0.532
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation WAS 0.564
Publications: 1 Organism: Mus Musculus
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation FCGR2C 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.486
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation MAPK14 0.486
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CLIC5 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DLG2 0.368
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.731
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ITPR1 0.489
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IKBKG 0.358
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTK2 0.6
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGAP33 0.463
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation FYN 0.529
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png dephosphorylation FYN 0.325
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation FYN 0.398
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FYN 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation ITCH 0.367
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation TXK 0.348
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA2 0.258
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTGS2 0.39
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CD5 0.493
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TOM1L1 0.435
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PGD 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLG4 0.564
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.327
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation FYN 0.398
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation FYN 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png dephosphorylation FYN 0.657
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png dephosphorylation FYN 0.657
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUP 0.559
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation JUP 0.559
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation DCBLD2 0.351
Publications: 7 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation NOX4 0.271
Publications: 1 Organism: In Vitro
+ down-regulates quantity img/direct_inhibition.png phosphorylation NFE2L2 0.402
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FYB1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TGFB1I1 0.341
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation KIRREL1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAG 0.427
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation MED28 0.447
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GRB10 0.381
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKACA 0.456
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.812
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.571
Publications: 2 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates quantity img/direct-activation.png phosphorylation APP 0.452
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPRT 0.416
Publications: 1
+ img/unknown.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCQ 0.345
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VAV1 0.634
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DAB1 0.613
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Dl 0.632
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Ml 0.632
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates quantity img/direct-activation.png phosphorylation LRP8 0.634
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPRF 0.398
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding FYN 0.538
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Dk 0.632
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/direct-activation.png binding FYN 0.382
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LCP2 0.754
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png phosphorylation FYN 0.423
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCR-Mk 0.632
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation