| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | FYN | Tyr420 | RLIEDNEyTARQGAK | phosphorylation up-regulates | 22080863 | SIGNOR-177109 |
| PTPN2 | FYN | Tyr420 | RLIEDNEyTARQGAK | dephosphorylation down-regulates | 22080863 | SIGNOR-177113 |
| FYN | FYN | Tyr420 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 9425276 | SIGNOR-251167 |
| PTPN5 | FYN | Tyr420 | RLIEDNEyTARQGAK | dephosphorylation down-regulates | 11983687 | SIGNOR-86791 |
| PTPRF | FYN | Tyr420 | RLIEDNEyTARQGAK | dephosphorylation down-regulates | 12496362 | SIGNOR-96768 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | phosphorylation up-regulates → | FYN PTyr420 | phosphorylation up-regulates → | FYN | 22080863 | SIGNOR-177109 |
| PTPN2 | dephosphorylation down-regulates ⊣ | FYN PTyr420 | dephosphorylation up-regulates → | FYN | 22080863 | SIGNOR-177113 |
| FYN | phosphorylation up-regulates → | FYN PTyr420 | phosphorylation up-regulates → | FYN | 9425276 | SIGNOR-251167 |
| PTPN5 | dephosphorylation down-regulates ⊣ | FYN PTyr420 | dephosphorylation up-regulates → | FYN | 11983687 | SIGNOR-86791 |
| PTPRF | dephosphorylation down-regulates ⊣ | FYN PTyr420 | dephosphorylation up-regulates → | FYN | 12496362 | SIGNOR-96768 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FYN | phosphorylation → up-regulates | FYN | SIGNOR-177109 |
| PTPN2 | dephosphorylation down-regulates | FYN | SIGNOR-177113 |
| FYN | phosphorylation → up-regulates activity | FYN | SIGNOR-251167 |
| PTPN5 | dephosphorylation down-regulates | FYN | SIGNOR-86791 |
| PTPRF | dephosphorylation down-regulates | FYN | SIGNOR-96768 |
