| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | RB1 | Ser249 | AVIPINGsPRTPRRG | phosphorylation down-regulates | 1756735 | SIGNOR-21548 |
| CyclinD/CDK4 | RB1 | Thr826 | LPTPTKMtPRSRILV | phosphorylation down-regulates activity | 9139732 | SIGNOR-216957 |
| CDK2 | RB1 | Thr821 | KISEGLPtPTKMTPR | phosphorylation down-regulates | 9139732 | SIGNOR-47895 |
| PRKAA1 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 19217427 | SIGNOR-184052 |
| ABL1 | RB1 | Tyr805 | RIPGGNIyISPLKSP | phosphorylation unknown | 16158058 | SIGNOR-140396 |
| CDK1 | RB1 | Ser807 | PGGNIYIsPLKSPYK | phosphorylation down-regulates | 1756735 | SIGNOR-21552 |
| CHEK1 | RB1 | Ser612 | MYLSPVRsPKKKGST | phosphorylation up-regulates activity | 17380128 | SIGNOR-153904 |
| CTDSPL | RB1 | Ser807 | PGGNIYIsPLKSPYK | dephosphorylation up-regulates activity | 15051889 | SIGNOR-248304 |
| CyclinD/CDK4 | RB1 | Thr356 | DSFETQRtPRKSNLD | phosphorylation down-regulates activity | 9139732 | SIGNOR-250760 |
| CyclinD/CDK4 | RB1 | Ser788 | PIPHIPRsPYKFPSS | phosphorylation down-regulates activity | 9139732 | SIGNOR-250759 |
| CDK18 | RB1 | – | phosphorylation unknown | 28361970 | SIGNOR-264558 | |
| CDK1 | RB1 | Thr373 | VNVIPPHtPVRTVMN | phosphorylation down-regulates | 1756735 | SIGNOR-21564 |
| MAPK14 | RB1 | Ser567 | SLAWLSDsPLFDLIK | phosphorylation down-regulates | 20871633 | SIGNOR-168178 |
| CDK1 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 1756735 | SIGNOR-21556 |
| PRKCB | RB1 | Ser780 | STRPPTLsPIPHIPR | phosphorylation down-regulates activity | 29088742 | SIGNOR-280083 |
| CDK6 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15809340 | SIGNOR-135189 |
| PPP2CA | RB1 | – | dephosphorylation up-regulates | 10702384 | SIGNOR-75398 | |
| CDK4 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15809340 | SIGNOR-135185 |
| CyclinD/CDK4 | RB1 | Thr5 | tPRKTAAT | phosphorylation down-regulates activity | 9139732 | SIGNOR-250762 |
| CDK4 | RB1 | Ser795 | SPYKFPSsPLRIPGG | phosphorylation down-regulates | 23336272 | SIGNOR-200487 |
| CyclinA2/CDK2 | RB1 | Thr821 | KISEGLPtPTKMTPR | phosphorylation down-regulates | 9139732 | SIGNOR-217324 |
| RAF1 | RB1 | – | phosphorylation down-regulates activity | 9819434 | SIGNOR-279481 | |
| CDK2 | RB1 | – | phosphorylation down-regulates | 21902831 | SIGNOR-176512 | |
| CDK3 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15084261 | SIGNOR-124212 |
| CDK5 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15741232 | SIGNOR-134468 |
| CyclinC/CDK3 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates activity | 15084261 | SIGNOR-273181 |
| CyclinD/CDK4 | RB1 | Ser780 | STRPPTLsPIPHIPR | phosphorylation down-regulates activity | 23336272 | SIGNOR-216988 |
| AMPK | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation unknown | 19217427 | SIGNOR-216635 |
| CDKL1 | RB1 | – | phosphorylation up-regulates activity | 28352193 | SIGNOR-273863 | |
| CDK4 | RB1 | Ser249 | AVIPINGsPRTPRRG | phosphorylation down-regulates | 15809340 | SIGNOR-135181 |
| CDK1 | RB1 | Thr252 | PINGSPRtPRRGQNR | phosphorylation down-regulates | 1756735 | SIGNOR-21560 |
| CHEK2 | RB1 | Ser612 | MYLSPVRsPKKKGST | phosphorylation up-regulates activity | 17380128 | SIGNOR-153908 |
| CTDSPL | RB1 | Ser811 | IYISPLKsPYKISEG | dephosphorylation up-regulates activity | 15051889 | SIGNOR-248305 |
| CDK4 | RB1 | Ser780 | STRPPTLsPIPHIPR | phosphorylation down-regulates | 23336272 | SIGNOR-200483 |
| CyclinD/CDK4 | RB1 | Ser795 | SPYKFPSsPLRIPGG | phosphorylation down-regulates activity | 23336272 | SIGNOR-216992 |
| CDK4 | RB1 | Thr826 | LPTPTKMtPRSRILV | phosphorylation down-regulates | 9139732 | SIGNOR-47899 |
| CyclinE/CDK2 | RB1 | Ser608 | TAADMYLsPVRSPKK | phosphorylation down-regulates activity | 10207050 | SIGNOR-250747 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | RB1 PSer249 | phosphorylation down-regulates ⊣ | RB1 | 1756735 | SIGNOR-21548 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PThr826 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-216957 |
| CDK2 | phosphorylation up-regulates → | RB1 PThr821 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-47895 |
| PRKAA1 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 19217427 | SIGNOR-184052 |
| ABL1 | phosphorylation up-regulates → | RB1 PTyr805 | phosphorylation down-regulates ⊣ | RB1 | 16158058 | SIGNOR-140396 |
| CDK1 | phosphorylation up-regulates → | RB1 PSer807 | phosphorylation down-regulates ⊣ | RB1 | 1756735 | SIGNOR-21552 |
| CHEK1 | phosphorylation up-regulates → | RB1 PSer612 | phosphorylation up-regulates → | RB1 | 17380128 | SIGNOR-153904 |
| CTDSPL | dephosphorylation down-regulates ⊣ | RB1 PSer807 | dephosphorylation down-regulates ⊣ | RB1 | 15051889 | SIGNOR-248304 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PThr356 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-250760 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PSer788 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-250759 |
| CDK1 | phosphorylation up-regulates → | RB1 PThr373 | phosphorylation down-regulates ⊣ | RB1 | 1756735 | SIGNOR-21564 |
| MAPK14 | phosphorylation up-regulates → | RB1 PSer567 | phosphorylation down-regulates ⊣ | RB1 | 20871633 | SIGNOR-168178 |
| CDK1 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 1756735 | SIGNOR-21556 |
| PRKCB | phosphorylation up-regulates → | RB1 PSer780 | phosphorylation down-regulates ⊣ | RB1 | 29088742 | SIGNOR-280083 |
| CDK6 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135189 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135185 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PThr5 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-250762 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer795 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-200487 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RB1 PThr821 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-217324 |
| CDK3 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15084261 | SIGNOR-124212 |
| CDK5 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15741232 | SIGNOR-134468 |
| CyclinC/CDK3 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15084261 | SIGNOR-273181 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PSer780 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-216988 |
| AMPK | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 19217427 | SIGNOR-216635 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer249 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135181 |
| CDK1 | phosphorylation up-regulates → | RB1 PThr252 | phosphorylation down-regulates ⊣ | RB1 | 1756735 | SIGNOR-21560 |
| CHEK2 | phosphorylation up-regulates → | RB1 PSer612 | phosphorylation up-regulates → | RB1 | 17380128 | SIGNOR-153908 |
| CTDSPL | dephosphorylation down-regulates ⊣ | RB1 PSer811 | dephosphorylation down-regulates ⊣ | RB1 | 15051889 | SIGNOR-248305 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer780 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-200483 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PSer795 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-216992 |
| CDK4 | phosphorylation up-regulates → | RB1 PThr826 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-47899 |
| CyclinE/CDK2 | phosphorylation up-regulates → | RB1 PSer608 | phosphorylation down-regulates ⊣ | RB1 | 10207050 | SIGNOR-250747 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | RB1 | SIGNOR-21548 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-216957 |
| CDK2 | phosphorylation down-regulates | RB1 | SIGNOR-47895 |
| PRKAA1 | phosphorylation down-regulates | RB1 | SIGNOR-184052 |
| ABL1 | phosphorylation → unknown | RB1 | SIGNOR-140396 |
| CDK1 | phosphorylation down-regulates | RB1 | SIGNOR-21552 |
| CHEK1 | phosphorylation → up-regulates activity | RB1 | SIGNOR-153904 |
| CTDSPL | dephosphorylation → up-regulates activity | RB1 | SIGNOR-248304 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-250760 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-250759 |
| CDK18 | phosphorylation → unknown | RB1 | SIGNOR-264558 |
| CDK1 | phosphorylation down-regulates | RB1 | SIGNOR-21564 |
| MAPK14 | phosphorylation down-regulates | RB1 | SIGNOR-168178 |
| CDK1 | phosphorylation down-regulates | RB1 | SIGNOR-21556 |
| PRKCB | phosphorylation → down-regulates activity | RB1 | SIGNOR-280083 |
| CDK6 | phosphorylation down-regulates | RB1 | SIGNOR-135189 |
| PPP2CA | dephosphorylation → up-regulates | RB1 | SIGNOR-75398 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-135185 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-250762 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-200487 |
| CyclinA2/CDK2 | phosphorylation down-regulates | RB1 | SIGNOR-217324 |
| RAF1 | phosphorylation → down-regulates activity | RB1 | SIGNOR-279481 |
| CDK2 | phosphorylation down-regulates | RB1 | SIGNOR-176512 |
| CDK3 | phosphorylation down-regulates | RB1 | SIGNOR-124212 |
| CDK5 | phosphorylation down-regulates | RB1 | SIGNOR-134468 |
| CyclinC/CDK3 | phosphorylation → down-regulates activity | RB1 | SIGNOR-273181 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-216988 |
| AMPK | phosphorylation → unknown | RB1 | SIGNOR-216635 |
| CDKL1 | phosphorylation → up-regulates activity | RB1 | SIGNOR-273863 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-135181 |
| CDK1 | phosphorylation down-regulates | RB1 | SIGNOR-21560 |
| CHEK2 | phosphorylation → up-regulates activity | RB1 | SIGNOR-153908 |
| CTDSPL | dephosphorylation → up-regulates activity | RB1 | SIGNOR-248305 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-200483 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-216992 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-47899 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | RB1 | SIGNOR-250747 |
