Summary

Name RB1
Full Name Retinoblastoma-associated protein
Synonyms p105-Rb, pRb, Rb, pp110
Primary ID P06400
Links - -
Type protein
Relations 45
Pathways IGF and Myogenesis, Cell cycle: G1/S phase transition, Malignant Melanoma, Luminal Breast Cancer
Function Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.84
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.48
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RB1
Publications: 2 Organism: , Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation RB1
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates img/direct-activation.png phosphorylation RB1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RB1
Publications: 6 Organism: Homo Sapiens, In Vitro
Pathways:Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma, IGF and Myogenesis
+ up-regulates activity img/direct-activation.png dephosphorylation RB1
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.23
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.17
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.21
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation RB1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.76
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RB1 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGA10
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png unknown Cell Cycle Block
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ down-regulates img/direct_inhibition.png binding ABL1 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding TRIP11 0.17
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown G1/S transition
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma
+ up-regulates img/direct-activation.png binding MYOD1 0.09
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/indirect-activation.png unknown HDAC3 0.21
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RB1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown RB1 0.61
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates img/direct-activation.png dephosphorylation RB1 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding E2F2 0.30
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding E2F1 0.86
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Luminal Breast Cancer, Malignant Melanoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RB1 0.09
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis