| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK4 | RB1 | Ser249 | AVIPINGsPRTPRRG | phosphorylation down-regulates | 15809340 | SIGNOR-135181 |
| CDK1 | RB1 | Ser249 | AVIPINGsPRTPRRG | phosphorylation down-regulates | 1756735 | SIGNOR-21548 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK4 | phosphorylation up-regulates → | RB1 PSer249 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135181 |
| CDK1 | phosphorylation up-regulates → | RB1 PSer249 | phosphorylation down-regulates ⊣ | RB1 | 1756735 | SIGNOR-21548 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK4 | phosphorylation![]() down-regulates | RB1 | SIGNOR-135181 |
| CDK1 | phosphorylation![]() down-regulates | RB1 | SIGNOR-21548 |