| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | RB1 | Thr821 | KISEGLPtPTKMTPR | phosphorylation down-regulates | 9139732 | SIGNOR-217324 |
| CDK2 | RB1 | Thr821 | KISEGLPtPTKMTPR | phosphorylation down-regulates | 9139732 | SIGNOR-47895 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation up-regulates → | RB1 PThr821 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-217324 |
| CDK2 | phosphorylation up-regulates → | RB1 PThr821 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-47895 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation![]() down-regulates | RB1 | SIGNOR-217324 |
| CDK2 | phosphorylation![]() down-regulates | RB1 | SIGNOR-47895 |