| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 1756735 | SIGNOR-21556 |
| CyclinC/CDK3 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates activity | 15084261 | SIGNOR-273181 |
| CDK6 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15809340 | SIGNOR-135189 |
| CDK4 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15809340 | SIGNOR-135185 |
| CDK5 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15741232 | SIGNOR-134468 |
| AMPK | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation unknown | 19217427 | SIGNOR-216635 |
| PRKAA1 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 19217427 | SIGNOR-184052 |
| CDK3 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15084261 | SIGNOR-124212 |
| CTDSPL | RB1 | Ser811 | IYISPLKsPYKISEG | dephosphorylation up-regulates activity | 15051889 | SIGNOR-248305 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 1756735 | SIGNOR-21556 |
| CyclinC/CDK3 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15084261 | SIGNOR-273181 |
| CDK6 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135189 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135185 |
| CDK5 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15741232 | SIGNOR-134468 |
| AMPK | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 19217427 | SIGNOR-216635 |
| PRKAA1 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 19217427 | SIGNOR-184052 |
| CDK3 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15084261 | SIGNOR-124212 |
| CTDSPL | dephosphorylation down-regulates ⊣ | RB1 PSer811 | dephosphorylation down-regulates ⊣ | RB1 | 15051889 | SIGNOR-248305 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | RB1 | SIGNOR-21556 |
| CyclinC/CDK3 | phosphorylation → down-regulates activity | RB1 | SIGNOR-273181 |
| CDK6 | phosphorylation down-regulates | RB1 | SIGNOR-135189 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-135185 |
| CDK5 | phosphorylation down-regulates | RB1 | SIGNOR-134468 |
| AMPK | phosphorylation → unknown | RB1 | SIGNOR-216635 |
| PRKAA1 | phosphorylation down-regulates | RB1 | SIGNOR-184052 |
| CDK3 | phosphorylation down-regulates | RB1 | SIGNOR-124212 |
| CTDSPL | dephosphorylation → up-regulates activity | RB1 | SIGNOR-248305 |
