| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | RB1 | Ser612 | MYLSPVRsPKKKGST | phosphorylation up-regulates activity | 17380128 | SIGNOR-153904 |
| CHEK2 | RB1 | Ser612 | MYLSPVRsPKKKGST | phosphorylation up-regulates activity | 17380128 | SIGNOR-153908 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | RB1 PSer612 | phosphorylation up-regulates → | RB1 | 17380128 | SIGNOR-153904 |
| CHEK2 | phosphorylation up-regulates → | RB1 PSer612 | phosphorylation up-regulates → | RB1 | 17380128 | SIGNOR-153908 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → up-regulates activity | RB1 | SIGNOR-153904 |
| CHEK2 | phosphorylation → up-regulates activity | RB1 | SIGNOR-153908 |