| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | RB1 | Ser807 | PGGNIYIsPLKSPYK | phosphorylation down-regulates | 1756735 | SIGNOR-21552 |
| CTDSPL | RB1 | Ser807 | PGGNIYIsPLKSPYK | dephosphorylation up-regulates activity | 15051889 | SIGNOR-248304 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | RB1 PSer807 | phosphorylation down-regulates ⊣ | RB1 | 1756735 | SIGNOR-21552 |
| CTDSPL | dephosphorylation down-regulates ⊣ | RB1 PSer807 | dephosphorylation down-regulates ⊣ | RB1 | 15051889 | SIGNOR-248304 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | RB1 | SIGNOR-21552 |
| CTDSPL | dephosphorylation → up-regulates activity | RB1 | SIGNOR-248304 |
