Entity Details

Name CyclinD/CDK4_Ser780
ID P06400
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinD/CDK4RB1Ser780STRPPTLsPIPHIPRphosphorylation
down-regulates activity		23336272SIGNOR-216988
CDK4RB1Ser780STRPPTLsPIPHIPRphosphorylation
down-regulates		23336272SIGNOR-200483
PRKCBRB1Ser780STRPPTLsPIPHIPRphosphorylation
down-regulates activity		29088742SIGNOR-280083
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinD/CDK4phosphorylation
up-regulates
→
RB1
PSer780		phosphorylation
down-regulates
⊣		RB123336272SIGNOR-216988
CDK4phosphorylation
up-regulates
→
RB1
PSer780		phosphorylation
down-regulates
⊣		RB123336272SIGNOR-200483
PRKCBphosphorylation
up-regulates
→
RB1
PSer780		phosphorylation
down-regulates
⊣		RB129088742SIGNOR-280083
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinD/CDK4phosphorylation
→
down-regulates activity 		RB1SIGNOR-216988
CDK4phosphorylation
img/direct_inhibition.png
down-regulates 		RB1SIGNOR-200483
PRKCBphosphorylation
→
down-regulates activity 		RB1SIGNOR-280083