| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK4 | RB1 | Ser795 | SPYKFPSsPLRIPGG | phosphorylation down-regulates | 23336272 | SIGNOR-200487 |
| CyclinD/CDK4 | RB1 | Ser795 | SPYKFPSsPLRIPGG | phosphorylation down-regulates activity | 23336272 | SIGNOR-216992 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK4 | phosphorylation up-regulates → | RB1 PSer795 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-200487 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PSer795 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-216992 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK4 | phosphorylation![]() down-regulates | RB1 | SIGNOR-200487 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-216992 |