Entity Details

Name CyclinD/CDK4_Thr826
ID P06400
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK4RB1Thr826LPTPTKMtPRSRILVphosphorylation
down-regulates		9139732SIGNOR-47899
CyclinD/CDK4RB1Thr826LPTPTKMtPRSRILVphosphorylation
down-regulates activity		9139732SIGNOR-216957
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK4phosphorylation
up-regulates
→
RB1
PThr826		phosphorylation
down-regulates
⊣		RB19139732SIGNOR-47899
CyclinD/CDK4phosphorylation
up-regulates
→
RB1
PThr826		phosphorylation
down-regulates
⊣		RB19139732SIGNOR-216957
Regulator Mechanism/Effect Target SIGNOR-ID
CDK4phosphorylation
img/direct_inhibition.png
down-regulates 		RB1SIGNOR-47899
CyclinD/CDK4phosphorylation
→
down-regulates activity 		RB1SIGNOR-216957